Results 21 to 30 of about 292,501 (293)
Diseases, 2021 With the approval and distribution of demonstrably safe COVID-19 vaccines bearing exceptionally high efficacy profiles, it may be tempting to envision a return to “normal” in the coming months.
Ilham M. Alshiraihi +2 more
doaj +1 more source
Hepatology, 2018 Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling.
Mengnuo Chen +12 more
semanticscholar +1 more source
Nature Communications, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. 2′-O-RNA methyltransferase (MTase) is one of the enzymes of this virus that is a potential target for antiviral therapy as it is crucial for RNA cap ...
P. Krafcikova +3 more
semanticscholar +1 more source
Plants, 2022 Berberine and berbamine are bioactive compounds of benzylisoquinoline alkaloids (BIAs) present in Berberis species. The contents of berbamine are 20 times higher than berberine in leaf tissues in three closely related species: Berberis koreana, B ...
Neha Samir Roy +10 more
doaj +1 more source
Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase
Nature Biotechnology, 2020 N6-Methyladenosine (m6A) is the most widespread internal messenger RNA modification in humans. Despite recent progress in understanding the biological roles of m6A, the inability to install m6A site specifically in individual transcripts has hampered ...
Christopher Wilson +3 more
semanticscholar +1 more source
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Cell Research, 2014 The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largely unknown.
X. Ping +24 more
semanticscholar +1 more source
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
Nucleic Acids Research, 2019 N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important m6A methyltransferases have been described functionally and structurally, but the enzymes responsible for ...
Nhan van Tran +10 more
semanticscholar +1 more source
5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader
Cell Research, 2017 5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown.
Xin Yang +23 more
semanticscholar +1 more source
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer
Cells, 2020 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs,
Anitha Chellamuthu, S. Gray
semanticscholar +1 more source
PRMT5 function and targeting in cancer
Cell Stress, 2020 Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic ...
Hyungsoo Kim, Ze’ev A. Ronai
doaj +1 more source