Results 21 to 30 of about 154,259 (119)
mSystems, 2019 To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya +5 more
doaj +1 more source
Epigenetics, 2023 N6-Methyladenosine (m6A) plays key roles in the regulation of biological functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs.
yongliang hua +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by ...
Xuda Liu +8 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundRecently, an increasing number of studies have uncovered the aberrant expression of methyltransferase-like family (METTL) plays an important role in tumorigenesis, such as METTL3 (an m6A writer).
Zhongji Jiang +14 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Lipopolysaccharide (LPS) and high-mobility group box 1 (HMGB1) are Toll-like receptor (TLR4) agonists that activate proinflammatory neuroimmune signaling linked to loss of basal forebrain cholinergic neurons (BFCNs) and cognitive deficits.
Fulton T. Crews +3 more
doaj +1 more source
New azodyrecins identified by a genome mining-directed reactivity-based screening
Beilstein Journal of Organic Chemistry, 2022 Only a few azoxy natural products have been identified despite their intriguing biological activities. Azodyrecins D–G, four new analogs of aliphatic azoxides, were identified from two Streptomyces species by a reactivity-based screening that targets ...
Atina Rizkiya Choirunnisa +11 more
doaj +1 more source
Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker [PDF]
arXiv, 2022 Background: RNA guanine-7 methyltransferase (RNMT) is one of the main regulators of N7-methylguanosine, and the deregulation of RNMT correlated with tumor development and immune metabolism. However, the specific function of RNMT in pan-cancer remains unclear.
arxiv
BcMettl4-Mediated DNA Adenine N6-Methylation Is Critical for Virulence of Botrytis cinerea
Frontiers in Microbiology, 2022 DNA adenine N6-methylation (6mA) plays a critical role in various biological functions, but its occurrence and functions in filamentous plant pathogens are largely unexplored. Botrytis cinerea is an important pathogenic fungus worldwide.
Zhengang Miao +5 more
doaj +1 more source
Novel Local Radiomic Bayesian Classifiers for Non-Invasive Prediction of MGMT Methylation Status in Glioblastoma [PDF]
arXiv, 2021 Glioblastoma, an aggressive brain cancer, is amongst the most lethal of all cancers. Expression of the O6-methylguanine-DNA-methyltransferase (MGMT) gene in glioblastoma tumor tissue is of clinical importance as it has a significant effect on the efficacy of Temozolomide, the primary chemotherapy treatment administered to glioblastoma patients ...
arxiv
Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus [PDF]
Open Biology, 2017 Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus.
Stephen K. Dolan +6 more
doaj +1 more source