Results 71 to 80 of about 4,190 (187)

Synergistic Anti‐Obesity Effect of Akkermansia muciniphila AKM Lab‐01 and Garcinia cambogia Extract via Gut Microbiota Remodeling in Diet‐Induced Obese Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Combined administration of pasteurized Akkermansia muciniphila (AKM Lab‐01) and Garcinia cambogia extract (GCE) alleviates high‐fat‐diet‐induced obesity in mice by reducing adiposity, metabolic disturbances, and adipose inflammation, while remodeling gut microbiota and adipose transcriptome, revealing a gut‐host metabolic axis that underpins the ...
Baojia Huang, Zhipeng Chen, Wenbin Xue, Zilun Pu, Yalin Zhou, Sherlyn Sze Ning Koay, Ping Kong, Yingying Zhao, Lihong Tai, Zhou Lan, Yibo Xian, Amanda Juan Chen   +11 more
wiley   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Unintentional toxicosis from methylxanthines in chocolate‐based baits consumed by American black bears

Wildlife Society Bulletin, 2016
The use of baits often increases success for many wildlife management activities, including wildlife capture for research, harvest by hunters and trappers during regulated activities, and lethal and nonlethal control for damage management.
Jeff Beringer, Andrew Timmins, Tim L. Hiller   +2 more
doaj   +1 more source

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

Methylxanthine Content in Green Tea Supplements: UHPLC Quantification, Method Validation, and Implications for Ergogenic Dosing in Athletes

Foods
Green tea supplements (GTSs) are a favorite among the general population and, due to their methylxanthine (caffeine, theobromine, theophylline) content, might represent a potential ergogenic source in athletes’ performance.
Iulia-Alexandra Paliu, Florin-Liviu Gherghina, Andrei Biţă, George Bică, Cornelia Bejenaru, Ludovic Everard Bejenaru, George Dan Mogoşanu, Andrei-Adrian Tica   +7 more
doaj   +1 more source

Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in Caenorhabditis elegans

Food Chemistry: X, 2019
Caffeine and related purine alkaloids are common ingredients of many stimulating drinks. Studies have shown that lower concentrations of caffeine have a protective role in aging-related disorders.
Hanmei Li, Mariana Roxo, Xinlai Cheng, Shaoxiong Zhang, Haoran Cheng, Michael Wink   +5 more
doaj   +1 more source

Cryoprotective Potential of Theobromine in the Improvement of the Post-Thaw Quality of Bovine Spermatozoa

Cells
Theobromine (TBR) is a methylxanthine known for its bronchodilatory and stimulatory effects. This research evaluated the vitality, capacitation patterns, oxidative characteristics, microbial profile and expression of capacitation-associated proteins ...
Filip Benko, Štefan Baňas, Michal Ďuračka, Miroslava Kačániová, Eva Tvrdá   +4 more
doaj   +1 more source

Physicochemical and Biochemical Changes in Cocoa during the Fermentation Step

Fermentation
The physicochemical and biochemical changes during the fermentation of four clones and two native varieties of Theobroma cacao L. were studied. Fermentation was performed in traditional wood cubes. During fermentation, the cotyledon pH decreased, and the
Franco Lucio Ruiz-Santiago, Facundo Joaquín Márquez-Rocha, Pedro García-Alamilla, Areli Carrera-Lanestosa, Carolina Ramírez-López, Erik Ocaranza-Sánchez, David Jesús Jiménez-Rodríguez   +6 more
doaj   +1 more source

Pharmacokinetics and Quantitative Structure–Pharmacokinetics Relationship Study of Xanthine Derivatives with Antidepressant, Anti-Inflammatory, and Analgesic Activity in Rats

Pharmaceutics
Objective: The aim of this study was to develop quantitative structure–pharmacokinetics relationship (QSPKR) models for a group of xanthine derivatives with proven pharmacological activity and to investigate its applicability for the prediction of the ...
Artur Świerczek, Małgorzata Szafarz, Agnieszka Cios, Jan Kobierski, Krzysztof Pociecha, Daniel Attard Saliba, Grażyna Chłoń-Rzepa, Elżbieta Wyska   +7 more
doaj   +1 more source