Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways [PDF]
Natural Products and Bioprospecting, 2023 Pseudospondias microcarpa is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has shown anxiolytic-like properties in mice anxiety models.
Donatus Wewura Adongo +10 more
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Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAB and Muscarinic Receptors [PDF]
Pharmaceuticals, 2023 Cleomin, a 1,3-oxazolidine-2-thione, was recently isolated from Neocalyptrocalyx longifolium, a species traditionally used for treating painful conditions. Reports about the pharmacological activities of cleomin are lacking.
Luíza Carolina França Opretzka +8 more
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Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model [PDF]
Future Science OAAims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais +6 more
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Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems [PDF]
Acta Dermato-VenereologicaPruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis
Go Kojima +6 more
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Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling [PDF]
Frontiers in Pharmacology, 2022 Korean scientists have shown that oral administration of Angelica gigas Nakai (AGN) root alcoholic extract and the metabolite of its pyranocoumarins, decursinol, have antinociceptive properties across various thermal and acute inflammatory pain models ...
LaTaijah C. Crawford +8 more
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Methysergide and Infantile Spasms
Pediatric Neurology Briefs, 1989 A trial of antiadrenergic and antiseretonergic drugs in the treatment of 24 newly diagnosed and previously untreated infantile spasm patients is reported from the Epilepsy Research Center, Section of Neurophysiology, Department of Neurology, Baylor ...
J Gordon Millichap
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Current Issues in Molecular Biology, 2022 Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee +3 more
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Acta Veterinaria, 2018 Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist.
Katarina Savić Vujović +7 more
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Brazilian Journal of Medical and Biological Research, 1998 The antinociceptive effects of stimulating the medial (ME) and central (CE) nuclei of the amygdala in rats were evaluated by the changes in the latency for the tail withdrawal reflex to noxious heating of the skin.
M.A. Oliveira, W.A. Prado
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Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. [PDF]
PLoS ONE, 2009 BACKGROUND: Mucociliary clearance in the airways is driven by the coordinated beating of ciliated cells. Classical neuromediators such as noradrenalin and acetylcholine increase ciliary beat frequency and thus cilia-driven transport.
Peter König +3 more
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