Results 41 to 50 of about 2,934 (153)
Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation
Mediators of Inflammation, 2000 We investigated morphological alterations induced by s.c. injection of 2.5 μg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves ...
Luis Roberto C. Gonçalves +1 more
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Journal of Pharmacological Sciences, 2007 The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada +7 more
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Fexofenadine Overcomes Osimertinib Resistance by Inhibiting c‐Met in Non‐Small Cell Lung Cancer
MedComm – Oncology, Volume 4, Issue 2, June 2025.Fexofenadine was identified as a new Met inhibitory drug by a computational drug repurposing tool called “DRAR‐CPI” via chemical‐protein interactome analysis of known Met inhibitors. It was shown to overcome osimertinib resistance in non‐small cell lung cancer by inhibiting Met in vitro and in vivo.
Kenneth K. W. To +2 more
wiley +1 more source
Pain Practice, Volume 25, Issue 5, June 2025.ABSTRACT Introduction Cluster headache is a rare primary headache disorder characterized by excruciating unilateral pain around the eye, lasting between 15 and 180 min, accompanied by ipsilateral cranial autonomic symptoms. Cluster headache is classified into two forms: episodic and chronic, with chronic cluster headache defined by pain‐free intervals ...
Casper S. Lansbergen +5 more
wiley +1 more source
PLoS ONE, 2013 Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors.
Rut Vleugels +4 more
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Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st‐century perspective
Experimental Physiology, Volume 109, Issue 8, Page 1217-1237, 1 August 2024.Abstract During mild or moderate exercise, alveolar ventilation increases in direct proportion to metabolic rate, regulating arterial CO2 pressure near resting levels. Mechanisms giving rise to the hyperpnoea of exercise are unsettled despite over a century of investigation.
Joseph F. Welch, Gordon S. Mitchell
wiley +1 more source
Revista Brasileira de Anestesiologia, 2010 JUSTIFICATIVA E OBJETIVOS: A fototerapia com laser (LPT) é um método analgésico promissor, embora seu mecanismo de ação não seja totalmente conhecido. O objetivo deste estudo foi avaliar se a ação da LPT é dependente da ativação de receptores opioides ou
André Peres e Serra, Hazem A Ashmawi
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The Journal of Physiology, Volume 602, Issue 5, Page 913-932, 1 March 2024.Abstract figure legend Left: the firing of wild‐type (WT) prenatal (embyronic day 17.5) lumbar spinal motoneurons (MNs) exhibiting a low input resistance (<100 MΩ) is inhibited by low frequency depolarizing GABAergic/glycinergic postsynaptic potentials (dGPSPs). Red dots indicate GABA/glycine terminals on the MN soma and proximal dendrites.
Hongmei Zhu +4 more
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Chemistry – A European Journal, Volume 30, Issue 10, February 16, 2024.A simple and effective organolithium approach to the synthesis of 2‐substituted benzo[cd]indoles from peri‐dihalonaphthalenes and nitriles has been developed. The reaction proceeds via a surprisingly easy intramolecular aromatic nucleophilic substitution facilitated by the “clothespin effect”.
Semyon V. Tsybulin +2 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 1967 A metisergide (butanolamida do ácido 1-metil-lisérgico) foi empregada experimentalmente em 78 pacientes com epilepsia psicomotora e com alterações focais (ondas "sharp") de projeção em um dos lobos temporais, no EEG.
Jorge Armbrust-Figueiredo
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