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Discovery of a PROTAC degrader for METTL3-METTL14 complex
Cell Chemical BiologyN6-methyladenosine (m6A) methylation is the most abundant type of RNA modification that is mainly catalyzed by the METTL3-METTL14 methyltransferase complex. This complex has been linked to multiple cancers and is considered a promising therapeutic target for acute myeloid leukemia (AML).
Xun Huang, Guobin Liu, Qiongyu Shi
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Lung
m6A RNA methylation is a critical epigenetic modification involved in the pathogenesis of pulmonary arterial hypertension (PAH). While macrophage-mediated inflammation plays a central role in PAH, the specific contributions of m6A regulators within macrophages are not yet fully understood.
Chunfeng, He +8 more
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m6A RNA methylation is a critical epigenetic modification involved in the pathogenesis of pulmonary arterial hypertension (PAH). While macrophage-mediated inflammation plays a central role in PAH, the specific contributions of m6A regulators within macrophages are not yet fully understood.
Chunfeng, He +8 more
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Fundamental & Clinical Pharmacology
AbstractBackgroundMany studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored ...
Rong Zhao +9 more
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AbstractBackgroundMany studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored ...
Rong Zhao +9 more
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Localization-dictated function for METTL3
Nature Cell Biology, 2022Sylvain Delaunay, Michaela Frye
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A Cleaved METTL3 Potentiates the METTL3-WTAP Interaction and Cancer Progression
SSRN Electronic Journal, 2022Chaojun Yan +12 more
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Role of m6A methyltransferase METTL3 in keratoconus pathogenesis
Experimental Eye ResearchKeratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (m6A) modification-related proteins in KC samples and human stromal keratocyte
Huimin Yu +8 more
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METTL3: Melting the tumor microenvironment for improved immunotherapy
Cell Chemical BiologyThe tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, "hot" TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
Longfei, Gao, Lei, Ding
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METTL3 contributes to the pathogenesis of AKI
Nature Reviews Nephrology, 2022openaire +2 more sources
METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy
CirculationBACKGROUND: Exercise improves functional outcomes in patients with diabetic cardiomyopathy (DiaCM). The molecular mechanism underlying cardiac benefits of exercise in DiaCM remains incompletely understood. N6-methyladenosine (m6A) is the most common form of messenger RNA modification in eukaryotes and has been implicated in ...
Chunyan Wang +14 more
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