Results 201 to 210 of about 17,358 (223)

Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function

Fundamental & Clinical Pharmacology
AbstractBackgroundMany studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored ...
Rong Zhao, Jiaping Chen, Yangwei Wang, Han Xiao, Peiyuan Mei, Wei Lin, Mingxin Diao, Shiwen He, Yongde Liao, Wangyang Meng   +9 more
openaire   +2 more sources

Localization-dictated function for METTL3

Nature Cell Biology, 2022
Sylvain Delaunay, Michaela Frye
openaire   +2 more sources

METTL3: Melting the tumor microenvironment for improved immunotherapy

Cell Chemical Biology
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, "hot" TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
Longfei, Gao, Lei, Ding
openaire   +2 more sources

Role of m6A methyltransferase METTL3 in keratoconus pathogenesis

Experimental Eye Research
Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (m6A) modification-related proteins in KC samples and human stromal keratocyte
Huimin Yu, Shengqian Dou, Huijin Wang, Yaru Sun, Junpeng Qu, Ting Liu, Xiaoxue Liu, Chao Wei, Hua Gao   +8 more
openaire   +2 more sources

A Cleaved METTL3 Potentiates the METTL3-WTAP Interaction and Cancer Progression

SSRN Electronic Journal, 2022
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
openaire   +1 more source

METTL3 contributes to the pathogenesis of AKI

Nature Reviews Nephrology, 2022
openaire   +2 more sources

A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease

Cell Metabolism, 2021
Harini Ramalingam, Patricia Cobo-Stark, Andrea Flaten   +2 more
exaly  

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Molecular Cell, 2022
Jia Xiong, Mao Jiang, Ke-Feng Ding
exaly  

METTL3 restrains autoimmunity in β-cells

Nature Cell Biology
Balasubramanian Krishnamurthy, Helen E. Thomas   +1 more
openaire   +2 more sources

METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer

Molecular Cancer, 2022
Wei Guo, Xiang Xu, Luo quan Ao
exaly