Results 211 to 220 of about 16,538 (257)

m6A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense. [PDF]

PLoS Pathog
Pok C, Gong AY, Graham ML, Wang S, Deng S, Sharmin Z, Lu E, Lu G, He C, Chen XM.   +9 more
europepmc   +1 more source

Interplay between N6-methyladenosine RNA methylation and protein lactylation: a novel crosstalk linking metabolism and epigenetic regulation in human diseases. [PDF]

J Transl Med
Gong Y, Liu Y.
europepmc   +1 more source

METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress. [PDF]

Mol Biol Rep
Zhang Y, Du X, Fu M, Hu H, Lu J, Pan T, Yuan L, Wu Y, Tong J.   +8 more
europepmc   +1 more source

METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes [PDF]

ChemMedChem, 2021
The methylase METTL3 is the writer enzyme of the N6 -methyladenosine (m6 A) modification of RNA. Using a structure-based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM, while its enantiomer is 100 ...
Elena Moroz, Amedeo Caflisch, Yaozong Li
exaly   +5 more sources

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UVB promotes melanogenesis by regulating METTL3

Journal of Cellular Physiology, 2023
AbstractUltraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although the mechanism has not been fully elucidated. N6‐methyladenosine (m6A) modification is one of the key epigenetic form of gene regulation that affects multiple biological processes.
Haoran Guo, Hongliang Zeng, Yibo Hu, Ling Jiang, Li Lei, Jinhua Hung, Chuhan Fu, Hui Li, Yan Long, Jing Chen, Qinghai Zeng   +10 more
openaire   +2 more sources

The Role of METTL3 in the Progression of Cardiac Fibrosis

Current Topics in Medicinal Chemistry, 2023
Abstract: Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive deposition of extracellular matrix proteins; this process is performed by a multifunctional cell known as the cardiac fibroblast. After the myocardial injury, these cells are activated as a repair program, increase, and switch to a contractile phenotype,
Samir Bolívar, Marian Pérez-Cantillo, Jassiris Monterroza-Torres, César Vásquez-Trincado, Jairo Castellar-Lopez, Evelyn Mendoza-Torres   +5 more
openaire   +2 more sources

RNA secondary structure dependence in METTL3–METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3

Biological Chemistry, 2020
Abstract N 6-methyladenosine (m6A) is the most abundant modification in mRNA. The core of the human N 6-methyltransferase complex (MTC) is formed by a heterodimer consisting of METTL3 and METTL14, which specifically catalyzes m6A formation within an RRACH sequence context.
Nathalie Meiser, Nicole Mench, Martin Hengesbach   +2 more
openaire   +2 more sources

METTL3: a multifunctional regulator in diseases

Molecular and Cellular Biochemistry
N6-methyladenosine (m6A) methylation is the most prevalent and abundant internal modification of mRNAs and is catalyzed by the methyltransferase complex. Methyltransferase-like 3 (METTL3), the best-known m6A methyltransferase, has been confirmed to function as a multifunctional regulator in the reversible epitranscriptome modulation of m6A modification
Na, Li, Xiang, Wei, Jian, Dai, Jinfeng, Yang, Sizheng, Xiong   +4 more
openaire   +2 more sources

METTL3 is required for maintaining β-cell function

Metabolism, 2021
N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β ...
Xinzhi, Li, Yuze, Jiang, Xu, Sun, Yongsen, Wu, Zheng, Chen   +4 more
openaire   +2 more sources