Results 211 to 220 of about 15,062 (245)

Localization-dictated function for METTL3

Nature Cell Biology, 2022
Sylvain Delaunay, Michaela Frye
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A Cleaved METTL3 Potentiates the METTL3-WTAP Interaction and Cancer Progression

SSRN Electronic Journal, 2022
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
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Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function

Fundamental & Clinical Pharmacology
AbstractBackgroundMany studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored ...
Rong Zhao, Jiaping Chen, Yangwei Wang, Han Xiao, Peiyuan Mei, Wei Lin, Mingxin Diao, Shiwen He, Yongde Liao, Wangyang Meng   +9 more
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METTL3: Melting the tumor microenvironment for improved immunotherapy

Cell Chemical Biology
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, "hot" TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
Longfei, Gao, Lei, Ding
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METTL3 contributes to the pathogenesis of AKI

Nature Reviews Nephrology, 2022
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METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy

Circulation
BACKGROUND: Exercise improves functional outcomes in patients with diabetic cardiomyopathy (DiaCM). The molecular mechanism underlying cardiac benefits of exercise in DiaCM remains incompletely understood. N6-methyladenosine (m6A) is the most common form of messenger RNA modification in eukaryotes and has been implicated in ...
Chunyan Wang, Siman Shen, Jiayi Kang, Aya Sugai-Munson, Xiao Xiao, Yajing Zhang, Junyuan Zhu, Zipeng Liu, Tina B. McKay, Oluwaseun Akeju, Eric R. Jonas, Amrut V. Ambardekar, Michael R. Bristow, Weifeng Yao, Haobo Li   +14 more
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Role of m6A methyltransferase METTL3 in keratoconus pathogenesis

Experimental Eye Research
Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (m6A) modification-related proteins in KC samples and human stromal keratocyte
Huimin Yu, Shengqian Dou, Huijin Wang, Yaru Sun, Junpeng Qu, Ting Liu, Xiaoxue Liu, Chao Wei, Hua Gao   +8 more
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METTL3 MODULATORS

2021
WYNN THOMAS ANDREW, HODOUS BRIAN LEWIS, BORIACK-SJODIN PAULA ANN, SICKMIER ERNEST ALLEN, MILLS JAMES EDWARD JOHN, COPELAND ROBERT A, SPARLING BRIAN ANDREW, DANIELS MATTHEW H, TASKER ANDREW STEWART, DUNCAN KENNETH W   +9 more
openaire   +6 more sources

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling

Cell Reports, 2023
Zhanghui Chen, Jing Tang, Guomei Su
exaly  

METTL3 MODULATORS

2022
MILLS JAMES EDWARD, DANIELS MATTHEW, WYNN THOMAS, SPARLING BRIAN, SICKMIER ERNEST, TASKER ANDREW   +5 more
openaire   +1 more source