Results 191 to 200 of about 17,358 (223)
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UVB promotes melanogenesis by regulating METTL3
Journal of Cellular Physiology, 2023AbstractUltraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although the mechanism has not been fully elucidated. N6‐methyladenosine (m6A) modification is one of the key epigenetic form of gene regulation that affects multiple biological processes.
Haoran Guo +10 more
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The Mettl3 epitranscriptomic writer amplifies p53 stress responses
Molecular Cell, 2022The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to uncover new mechanisms through which p53 regulates gene expression using tandem affinity purification/mass spectrometry to identify p53-interacting proteins.
Nitin Raj +17 more
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METTL3 is required for maintaining β-cell function
Metabolism, 2021N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β ...
Xinzhi, Li +4 more
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Roles of METTL3 in cancer: mechanisms and therapeutic targeting [PDF]
Journal of Hematology and Oncology, 2020 AbstractN6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence in recent years reveals that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA ...
Chengwu Zeng, Wanxu Huang, Yangqiu Li
exaly +4 more sources
Biological Chemistry, 2020
Abstract N 6-methyladenosine (m6A) is the most abundant modification in mRNA. The core of the human N 6-methyltransferase complex (MTC) is formed by a heterodimer consisting of METTL3 and METTL14, which specifically catalyzes m6A formation within an RRACH sequence context.
Nathalie Meiser +2 more
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Abstract N 6-methyladenosine (m6A) is the most abundant modification in mRNA. The core of the human N 6-methyltransferase complex (MTC) is formed by a heterodimer consisting of METTL3 and METTL14, which specifically catalyzes m6A formation within an RRACH sequence context.
Nathalie Meiser +2 more
openaire +2 more sources
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation [PDF]
Cell Research, 2017 METTL3 catalyzes the formation of N6-methyl-adenosine (m6A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was essential for male fertility and spermatogenesis.
Kai Xu, Ying Yang, Baofa Sun
exaly +3 more sources
The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension
Life Sciences, 2021N6-methyladenosine (m6A) is the most prevalent internal chemical RNA modification in mammal mRNAs. Accumulating evidence has shown the critical role of m6A in cardiovascular diseases including cardiac hypertrophy, heart failure, ischemic heart disease, vascular calcification, restenosis, and aortic aneurysm.
Yuhan, Qin +7 more
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METTL3: a multifunctional regulator in diseases
Molecular and Cellular BiochemistryN6-methyladenosine (m6A) methylation is the most prevalent and abundant internal modification of mRNAs and is catalyzed by the methyltransferase complex. Methyltransferase-like 3 (METTL3), the best-known m6A methyltransferase, has been confirmed to function as a multifunctional regulator in the reversible epitranscriptome modulation of m6A modification
Na, Li +4 more
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Lung
m6A RNA methylation is a critical epigenetic modification involved in the pathogenesis of pulmonary arterial hypertension (PAH). While macrophage-mediated inflammation plays a central role in PAH, the specific contributions of m6A regulators within macrophages are not yet fully understood.
Chunfeng, He +8 more
openaire +2 more sources
m6A RNA methylation is a critical epigenetic modification involved in the pathogenesis of pulmonary arterial hypertension (PAH). While macrophage-mediated inflammation plays a central role in PAH, the specific contributions of m6A regulators within macrophages are not yet fully understood.
Chunfeng, He +8 more
openaire +2 more sources