Results 1 to 10 of about 7,941 (215)
YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy [PDF]
Frontiers in Oncology, 2021 BackgroundYTH N6-methyladenosine RNA binding protein 1 (YTHDF1) has been indicated proven to participate in the cross-presentation of tumor antigens in dendritic cells and the cross-priming of CD8+ T cells.
Dongxu Qiu, Anze Yu, Hao Deng
exaly +5 more sources
Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma
Frontiers in Genetics, 2022 Background: YTHDF1 is highly expressed in multiple tumors and affects tumor progression. However, there are only a few comprehensive studies on the analysis of YTHDF1 in esophageal cancer.Methods: We analyzed YTHDF1 expression in pan-cancer by comparing ...
Xu-Sheng Liu, Zhi-Jun Pei
exaly +5 more sources
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non–small-cell lung cancer [PDF]
OncoImmunology, 2021 The human YTH domain family (YTHDF) proteins are RNA-binding proteins that recognize N6-methyladenosine (m6A), facilitating various biological processes via m6A RNA modification.
Kazuo Tsuchiya +12 more
doaj +2 more sources
YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2
Frontiers in Oncology, 2021 N6-methyladenosine (m6A) is the most common post-transcriptional modification of RNA in eukaryotes, which has been demonstrated to play important roles in various cancers. YTHDF1 acts as a crucial m6A “reader” and regulates the fate of m6A modified mRNA.
Haocheng Wang +8 more
exaly +3 more sources
YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer [PDF]
Signal Transduction and Targeted TherapyN6-methyladenosine (m6A) modification of mRNAs is a predominant epigenetic regulatory mechanism in tumor initiation and progression. Cancer stem cells (CSCs) are the key drivers of colorectal cancer (CRC) initiation and chemotherapy resistance.
Henley Cheung +16 more
doaj +2 more sources
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
Frontiers in Oncology, 2019 YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA methylation modification. Recent studies have shown that m6A is closely related to multiple tumors, thus YTHDF1 may also play a role in tumorigenesis.
Lihua Huang, Changwei Lin
exaly +3 more sources
Frontiers in Cell and Developmental Biology, 2021 ObjectivesN6-methyladenosine (m6A) RNA methylation is implicated in the progression of multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in gastric cancer (GC), while the biological mechanisms via which YTHDF1 regulates ...
Xiao-Yu Chen, Jing Zhang, Jinshui Zhu
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Advanced Science, 2021 Messenger RNA m6A modification is shown to regulate local translation in axons. However, how the m6A codes in axonal mRNAs are read and decoded by the m6A reader proteins is still unknown. Here, it is found that the m6A readers YTHDF1 and YTHDF2 are both
Sheng-Jian Ji
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YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS
Cell ReportsSummary: N6-methyladenosine (m6A) modification has been implicated in many cell processes and diseases. YTHDF1, a translation-facilitating m6A reader, has not been previously shown to be related to allergic airway inflammation.
Jing Wang +13 more
exaly +3 more sources
Frontiers in Oncology, 2022 BackgroundYTH domain-containing family protein 1 (YTHDF1) or YTHDF2 play crucial roles in cancer immunotherapy. We examine the expression of YTHDF1, YTHDF2, CD8, CD4, and FOXP3 to identify their prognostic or predictive role for PD-1/PD-L1 inhibitor in ...
Young Wha Koh +3 more
doaj +1 more source