Results 21 to 30 of about 7,941 (215)

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells [PDF]

, 2022
[EN] Objectives Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet ...
Bhagat, Govind, Bilbao Catalá, José Ramón, Castellanos Rubio, Ainara, García Santisteban, Iraia, Godbout, Julie K., Green, Peter H., He, Chuan, Herrero, Laura, Huerta Madrigal, Alain, Irastorza Terradillos, Iñaki Xarles, Mendoza Gómez, Luis Manuel, Mera, Paula, Olazagoitia Garmendia, Ane, Rodríguez Pérez, José Antonio, Sebastián de la Cruz, Maialen, Serra, Dolors, Verdú, Elena F., Zhang, Linda   +17 more
core   +1 more source

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism [PDF]

, 2021
Background: N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing are two of the most abundant RNA modification events affecting adenosines in mammals.
Cesarini, Valeriana, De Angelis, Biagio, De Luca, Gabriele, Fatica, Alessandro, Gallo, Angela, Ginistrelli, Lavinia Ceci, Ianniello, Zaira, Locatelli, Franco, Martini, Maurizio, Silvestris, Domenico Alessandro, Tassinari, Valentina, Tomaselli, Sara, Vitiani, Lucia Ricci   +12 more
core   +1 more source

Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease [PDF]

, 2020
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that develops due to the interaction between genetic and environmental factors.
Castellanos Rubio, Ainara, García Etxebarria, Koldo, Gonzalez Moro, Itziar, Olazagoitia Garmendia, Ane, Santín Gómez, Izortze, Sebastián de la Cruz, Maialen   +5 more
core   +3 more sources

Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells

Journal for ImmunoTherapy of Cancer, 2022
Background Gastric cancer (GC) is one of the most common cancer worldwide. We analyzed the expression of m6A regulatory genes in GC cohorts and revealed that YTHDF1 was uniquely upregulated in GC as compared with adjacent normal tissues.
Jun Yu, Yu Shi, Sachiyo Nomura, Wei Kang, Chi Chun Wong, Weixin Liu, Jianning Zhai, Huarong Chen, Xiaowu Bai, Yasi Pan, Masami Yamamoto, Tetsuya Tsukamoto, Philip Chiu, Enders Kwok-wai Ng   +13 more
doaj   +1 more source

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

Experimental Hematology & Oncology, 2021
Background N 6-methyladenosine (m6A) modification, as the most abundant RNA modification, widely participates in the physiological process and is involved in multiple disease progression, especially cancer.
Xiangyuan Luo, Mengdie Cao, Fan Gao, Xingxing He   +3 more
doaj   +1 more source

m6A facilitates hippocampus-dependent learning and memory through YTHDF1 [PDF]

Nature, 2018
N6-methyladenosine (m6A), the most prevalent internal RNA modification on mammalian messenger RNAs, regulates the fates and functions of modified transcripts through m6A-specific binding proteins1-5. In the nervous system, m6A is abundant and modulates various neural functions6-11.
Shi, Hailing, Zhang, Xuliang, Weng, Yi-Lan, Lu, Zongyang, Liu, Yajing, Lu, Zhike, Li, Jianan, Hao, Piliang, Zhang, Yu, Zhang, Feng, Wu, You, Delgado, Jary Y., Su, Yijing, Patel, Meera J., Cao, Xiaohua, Shen, Bin, Huang, Xingxu, Ming, Guo-li, Zhuang, Xiaoxi, Song, Hongjun, He, Chuan, Zhou, Tao   +21 more
openaire   +2 more sources

Unlocking Dendritic Cell-Based Vaccine Efficacy through Genetic Modulation:How Soon Is Now? [PDF]

, 2023
The dendritic cell (DC) vaccine anti-cancer strategy involves tumour-associated antigen loading and maturation of autologous ex vivo cultured DCs, followed by infusion into the cancer patient.
Bennett, Jason, Bridgewater, Hannah, Elwakeel, Ahmed Abdelmageed Saad Ahmed   +2 more
core   +1 more source

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner

Cell & Bioscience, 2022
Background N6-methyladenosine (m6A) is the most common post-transcriptional modification at the RNA level. However, the exact molecular mechanisms of m6A epigenetic regulation in breast cancer remain largely unknown and need to be fully elucidated ...
Hengyu Chen, Yuanhang Yu, Ming Yang, Haohao Huang, Shenghui Ma, Jin Hu, Zihan Xi, Hui Guo, Guojie Yao, Liu Yang, Xiaoqing Huang, Feng Zhang, Guanghong Tan, Huangfu Wu, Wuping Zheng, Lei Li   +15 more
doaj   +1 more source

The human RBPome: From genes and proteins to human disease [PDF]

, 2015
RNA binding proteins (RBPs) play a central role in mediating post transcriptional regulation of genes. However less is understood about them and their regulatory mechanisms.
Hashemikhabir, Seyedsasan, Janga, Sarath Chandra, Neelamraju, Yaseswini   +2 more
core   +1 more source

m^6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
A Minajigi, A Wutz, A Wutz, AJ Link, AM Hartmann, Amy Chow, B Linder, B Moindrot, Brian F. Pickering, C Chu, CA McHugh, Chun-Kan Chen, CM Wei, Constanza Jackson, CR Alarcón, D Dominissini, Deepak P. Patil, F Ramírez, FL Wilkinson, G Jia, G Singh, GD Penny, H Uranishi, I Huppertz, J Kochan, J König, J Schindelin, J Zhao, JA Bokar, JM Engreitz, K Horiuchi, K Morohashi, K Plath, KD Meyer, KD Meyer, KD Meyer, L Berglund, L Bylund, Mitchell Guttman, MJ Cowley, N Liu, P Shannon, Q Cao, S Geula, S Heinz, S Niranjanakumari, S Schwartz, S Zhong, Samie R. Jaffrey, SC Kwon, SD Agarwala, SM Weyn-Vanhentenryck, W Ma, W Xiao, X Wang, X Wang, XL Ping, Y Hasegawa, YC Lin   +58 more
core   +2 more sources