Results 41 to 50 of about 7,941 (215)
Stem Cells International, 2023 N6-methyladenosine (m6A) mRNA methylation has emerged as an important player in many biological processes by regulating gene expression. As a crucial reader, YTHDF1 usually improves the translation efficiency of its target mRNAs.
Xiang Gao +4 more
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses [PDF]
, 2022 We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most ...
Criner, Gerard J. +22 more
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YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice
International Journal of Molecular Sciences, 2023 The brain-gut axis (BGA) is a significant bidirectional communication pathway between the brain and gut. Traumatic brain injury (TBI) induced neurotoxicity and neuroinflammation can affect gut functions through BGA. N6-methyladenosine (m6A), as the most popular posttranscriptional modification of eukaryotic mRNA, has recently been identified as playing
Peizan Huang +4 more
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Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis [PDF]
Cancer Cell International, 2020 Abstract Background The incidence and mortality of melanoma is increasing around the world. To deeply explain the mechanism insight into it, we conducted a systematic analysis to examine the levels of regulatory genes of the common RNA epigenetic modification-N6-methyladenosine (m6A) in patients with melanoma compared by the healthy.
Tengda Li +3 more
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Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. [PDF]
, 2012 DARPP-32 (dopamine and adenosine 3\u27, 5\u27-cyclic monophosphate cAMP-regulated phosphoprotein, 32 kDa) is a striatal-enriched protein that mediates signaling by dopamine and other first messengers in the medium spiny neurons.
Beck, Heike +9 more
core +2 more sources
Molecular Therapy: Nucleic Acids, 2020 Hepatocellular carcinoma (HCC), one of the most aggressive malignancies, ranks as the fourth leading cause of cancer-related deaths worldwide. Emerging evidence indicates that RNA N6-methyladenosine (m6A) plays a critical role in tumor progression ...
Xiangxiang Liu +15 more
doaj +1 more source
N6-methyladenosine reader YTHDF1 regulates the proliferation and migration of airway smooth muscle cells through m6A/cyclin D1 in asthma [PDF]
PeerJ, 2023 Asthma is a chronic inflammatory respiratory disease, which is involved in multiple pathologic molecular mechanisms and presents a huge challenge to clinic nursing.
Juan Wang +3 more
doaj +2 more sources
Research Progress on the Role of M6A Methylation Modification in the Genesis and Development of GC [PDF]
, 2023 Modifcation of M6ARNAmethylation is the most prevalent form of RNAediting in eukaryotic organisms. The m6A-methylated regulatory protein is intimately associated with biological processes, including GC proliferation, invasion, and metastasis.
Jiang, Wenjun, Li, Ya
core +1 more source
Cell Death and Disease, 2021 N6-methyladenosine (m6A) is required for differentiation of human bone marrow mesenchymal stem cells (hBMSCs). However, its intrinsic mechanisms are largely unknown.
Tao Liu +12 more
doaj +1 more source
Theranostics, 2021 N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m6A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneration remains unclear.
Han, Zhenbo +28 more
openaire +2 more sources