Results 31 to 40 of about 7,941 (215)

The m⁶A Reader YTHDF1 Promotes Lung Carcinoma Progression via Regulating Ferritin Mediate Ferroptosis in an m⁶A-Dependent Manner

Pharmaceuticals, 2023
N6-methyladenosine (m6A) plays a significant role as an epigenetic mechanism, which is involved in various cancers’ progress via regulating mRNA modification.
Hongtao Diao, Huiling Tan, Yaju Hu, Ruonan Wang, Pingdong Cai, Bingying Huang, Xiaoqi Shao, Meiling Yan, Chuntong Yin, Yue Zhang   +9 more
doaj   +1 more source

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]

, 2017
Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven), Calderone, V. (Vittorio), Elkon, R. (Ran), Han, R. (Ruiqi), Loayza-Puch, F. (Fabricio), Slobodin, B. (Boris), Vrielink, J.A.F.O. (Joachim A.F. Oude)   +6 more
core   +4 more sources

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Signal Transduction and Targeted Therapy, 2021
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia.
Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang, Jing Xu, Hong Yang, Yuanchang Hu, Jiannan Qiu, Liyong Pu, Jinhai Tang, Xuehao Wang   +10 more
doaj   +1 more source

Investigating the Oncogenic and Immunological Implications of YTHDF1 in Ovarian Cancer. [PDF]

Biologics
Ovarian cancer (OC) ranks among the most lethal and aggressive gynecological malignancies. Identifying novel molecular targets is crucial for improving early diagnosis and developing effective therapies. Despite advancements in immunotherapy, its efficacy in OC remains limited due to the absence of well-defined immune-related molecular targets.This ...
Yin B, Zhou H.
europepmc   +4 more sources

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium [PDF]

, 2017
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium ...
Albert, C.M. (Christine), Alonso, A. (Alvaro), Arking, D.E. (Dan), Barnard, J. (John), Benjamin, E.J. (Emelia), Bis, J.C. (Joshua), Chasman, D.I. (Daniel), Christophersen, I.E. (Ingrid E.), Chung, M.K. (Mina K.), Conen, D. (David), Delgado, G., Denny, J.C. (Joshua C.), Dörr, M. (Marcus), Ellinor, P.T. (Patrick), Engström, G., Felix, S.B. (Stephan), Ford, I. (Ian), Franco, O.H. (Oscar H.), Geelhoed, B. (Bastiaan), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Harris, T.B. (Tamara), Heckbert, S.R. (Susan), Heeringa, J. (Jan), Jukema, J.W. (Jan Wouter), Klarin, D. (Derek), Kleber, M.E. (Marcus), Krijthe, B.P. (Bouwe P.), Kähönen, M. (Mika), Kääb, S. (Stefan), Launer, L.J. (Lenore), Lehtimäki, T. (Terho), Lin, H.J. (Henry J.), Lubitz, S.A. (Steven), Lunetta, K.L. (Kathryn), Lyytikäinen, L.-P. (Leo-Pekka), MacFarlane, P.W. (Peter), Martinsson, A. (Andreas), Melander, O. (Olle), März, W. (Winfried), Müller-Nurasyid, M. (Martina), Nikus, K. (Kjell), Pare, G. (Guillame), Psaty, B.M. (Bruce M.), Rienstra, S.A., Roden, D.M. (Dan), Rose, L.M. (Lynda), Rotter, J.I. (Jerome I.), Shoemaker, M.B. (M. Benjamin), Sinner, M.F. (Moritz), Smith, A.V. (Albert Vernon), Smith, J.D. (Jonathan), Smith, J.G. (J Gustav), Soliman, E.Z. (Elsayed), Sotoodehnia, N. (Nona), Stricker, B.H.Ch. (Bruno), Taylor, K.D. (Kent), Teixeira, P.L. (Pedro L.), Teumer, A. (Alexander), Thériault, S. (Sébastien), Trompet, S. (Stella), Uitterlinden, A.G. (André), Van Der Harst, P. (Pim), Verweij, N. (Niek), Völker, U. (Uwe), Wagoner, D.R. (David) van, Waldenberger, M. (Melanie), Weeke, P.E. (Peter E.), Weng, L.-C., Yao, J. (Jiefen)   +69 more
core   +1 more source

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases [PDF]

, 2022
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with key events of cardiovascular diseases and metabolic disorders.
Kankuri, Esko, Sikorski, Vilbert, Vento, Antti   +2 more
core   +2 more sources

Regulation of HuR structure and function by dihydrotanshinone-I [PDF]

, 2017
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs.
Abdelmohsen, Kotb, Biasini, Emiliano, Bonomo, Isabelle, Cerofolini, Linda, D'Agostino, Vito Giuseppe, Dassi, Erik, Dixon, Dan A., Elezgarai, Saioa R., Fairlamb, Max S., Fragai, Marco, Fuccio, Carmelo, Giuntini, Stefano, Gorospe, Myriam, Lal, Preet, Lehrmann, Elin, Luchinat, Claudio, Maio, Danilo Di, Manzoni, Leonardo, Marinelli, Luciana, Munk, Rachel, Novellino, Ettore, Preet, Ranjan, Provenzani, Alessandro, Quattrone, Alessandro, Seneci, Pierfausto, Vishwakarma, Vikalp, Williams, Sha Neisha, Zucal, Chiara   +27 more
core   +2 more sources

Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma

Cancers, 2023
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy that commonly affects older individuals with a high mortality rate [...]
Aayami Jaguri, Martin Steinhoff, Aamir Ahmad   +2 more
openaire   +2 more sources

The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]

, 2017
YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara, Carrieri, Claudia, Di Giacomo, Monica, Enright, Anton J, Ivanova, Ivayla, Monahan, Jack, Moreira, Pedro N, Morgan, Marcos, Much, Christian, O'Carroll, Dónal   +9 more
core   +3 more sources

Multiple roles of m6A RNA modification in translational regulation in cancer [PDF]

, 2022
Despite its discovery in the early 1970s, m(6)A modification within mRNA molecules has only powerfully entered the oncology field in recent years. This chemical modification can control all aspects of the maturation of mRNAs, both in the nucleus and in ...
Alessandro Fatica, Bianca Cesaro, Guillermo Fernandez Rodriguez   +2 more
core   +1 more source