Results 11 to 20 of about 7,941 (215)
The function and clinical implication of YTHDF1 in the human system development and cancer
Biomarker Research, 2023 YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mechanisms, such as promoting protein translation
Wenjun Ren +5 more
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YTHDF1 in Tumor Cell Metabolism: An Updated Review
Molecules, 2023 With the advancement of research on m6A-related mechanisms in recent years, the YTHDF protein family within m6A readers has garnered significant attention.
Haichuan Rong +4 more
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Research Progress on Relation Between YTHDF1 and Tumors
Zhongliu Fangzhi Yanjiu, 2020 N6-methyladenosine (m6A) modification is the most common, abundant and conservative posttranscriptional modification. More and more evidence suggest that via various mechanisms, it has a certain impact on tumors, such as liver cancer, gastric cancer ...
XIAO Shiwei +3 more
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YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Cell Death and Disease, 2022 Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance.
Yu Sun +5 more
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YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation [PDF]
Cell Proliferation, 2021 AbstractObjectivesYTHDF1 is known as a m6A reader protein, and many researches of YTHDF1 focused on the regulation of mRNA translation efficiency. However, YTHDF1 is also related to RNA degradation, but how YTHDF1 regulates mRNA degradation is indefinite.
Jiong Li +17 more
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BMC MedicineBackground Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1), an m6A-binding protein, from the periaqueductal gray (PAG) reportedly ...
Chaopeng Ou +8 more
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Potential Impact of ALKBH5 and YTHDF1 on Tumor Immunity in Colon Adenocarcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundALKBH5 and YTHDF1 are regarded as the eraser and reader, respectively, in N6-methyladenosine (m6A) modification. Recently, immune contexture has been drawing increasing attention in terms of the progression and treatment of cancers. This study aimed to determine the relationship between ALKBH5/YTHDF1 and immunological characteristics of colon
Guanyu Yan +5 more
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YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
International Journal of Molecular Sciences, 2023 N6-methyladenosine (m6A) is the most common mRNA modification and it plays a critical role in tumor progression, prognoses and therapeutic response. In recent years, more and more studies have shown that m6A modifications play an important role in bladder carcinogenesis and development.
Junlong Zhu +5 more
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Prognostic values of YTHDF1 regulated negatively by mir‐3436 in Glioma [PDF]
Journal of Cellular and Molecular Medicine, 2020 Abstract M6A methylation is likely to be closely associated with the occurrence and development of tumours. In this study, we demonstrated that the transcription levels of the m6A RNA methylation regulators are closely related to the prognosis of glioma.
Chenyang Xu +4 more
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European Journal of Medical Research, 2023 Purpose There is no report about the direct relationship between m6A modification and androgen receptor (AR)-related genes in prostate cancer (PC).
Qihong Nie +5 more
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