Results 61 to 70 of about 7,941 (215)

RNA Methylation and Ythdf Readers in Posttranscriptional Regulation and Development [PDF]

, 2021
Development in animals requires precise and coordinated changes in gene expression. This genetic remodeling is achieved through extensive regulatory networks of proteins and RNAs that function together to specify new cell fates and patterns.
Kontur, Cassandra
core   +1 more source

Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration [PDF]

, 2022
The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the decline of cognitive function ...
Castro Hernández, Ricardo
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Noncanonical function of epigenetic reader YTHDF1 inhibits MASLD progression by maintaining peroxisomes and mitochondrial homeostasis

Experimental and Molecular Medicine
YTH N 6-methyladenosine RNA binding protein F1 (YTHDF1) enables N 6-methyladenosine-containing RNA binding activity, involved in mRNA destabilization and positive regulation of translational initiation.
Chenyang Mu, Jian Tan, Yuefan Wang, Haozan Yin, Zhihui Dai, Zenghan Wang, Dongyang Ding, Zhichao Zhang, Sijie Wang, Hui Liu, Fu Yang   +10 more
doaj   +1 more source

From form to function: m6A methylation links mRNA structure to metabolism [PDF]

, 2022
Reversible N6-methyladenosine (m6A) RNA modification is a posttranscriptional epigenetic modification of the RNA that regulates many key aspects of RNA metabolism and function. In this review, we highlight major recent advances in the field, with special
Darsinou, Marousa, Martinez De La Cruz, Braulio, Riccio, Antonella   +2 more
core  

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development [PDF]

, 2022
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell ...
Cao, Hongguo, Cao, Zhikun, Chang, Yuguang, Felici, Massimo De, Feng, Yanqin, Ge, Wei, Muhammad, Zafir, Shen, Wei, Wang, Jing, Yan, Zihui, Yi, Mingliang, Zhang, Zijun, Zhou, Tingting   +12 more
core   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

YTHDF1-enhanced iron metabolism depends on TFRC m⁶A methylation

Theranostics, 2020
Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a crucial role in tumor progression, is mainly regulated by alterations to genes and post-transcriptional processes. The recent discovery of the N6-methyladenosine (m6A) modification has
Ye, Jing, Wang, Zhanggui, Chen, Xiaozhen, Jiang, Xiaohua, Dong, Zhihuai, Hu, Sunhong, Li, Wenya, Liu, Yuehui, Liao, Bing, Han, Weidong, Shen, Jiaying, Xiao, Mang   +11 more
openaire   +2 more sources

Up-Regulation of YTHDF1 and YTHDF3 is Related to the Prognosis of Oral Squamous Cell Carcinoma [PDF]

, 2021
Abstract Background N6-methyladenosine (m6A) is the most abundant internal modification in mammalian mRNAs. M6A is composed of methyl-transferases, which act as ("writers"), binding proteins, which act as ("readers"), and demethylases, which act as ("erasers").
Rui Shi, Shao-ming Li, Ling Gao, Ke-qian Zhi, wen-hao ren   +4 more
openaire   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source