Results 71 to 80 of about 7,941 (215)

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

Nature Communications, 2023
YTHDF1 is an m6A reader that binds to methylated RNA and facilitates translation. Here the authors show that tumor intrinsic YTHDF1 promotes tumorigenesis by regulating lysosomal proteolysis of MHC-I and that YTHDF1 targeting boosts anti-tumor immunity ...
Wanzun Lin, Li Chen, Haojiong Zhang, Xianxin Qiu, Qingting Huang, Fangzhu Wan, Ziyu Le, Shikai Geng, Anlan Zhang, Sufang Qiu, Long Chen, Lin Kong, Jiade J. Lu   +12 more
doaj   +1 more source

Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection [PDF]

, 2020
The RNA modification N6-methyladenosine (m6A) modulates mRNA fate and thus affects many biological processes. We analyzed m6A across the transcriptome following infection by dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), and hepatitis C ...
Gokhale, N.S., Holley, C.L., Horner, S.M., Lazear, H.M., Mason, C.E., Mattocks, M.D., McIntyre, A.B.R.   +6 more
core   +2 more sources

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation [PDF]

RNA Biology, 2020
N6-methyladenosine (m6A) has emerged as a crucial epitranscriptomic mark which regulates a broad spectrum of physiological processes including stem cell differentiation. m6A-binding YTHDF proteins have recently been proposed to mediate differentiation of leukemia cell in a redundant manner.
Shen Wang, Jun Zhang, Xiang Wu, Xianrong Lin, Xiao-Min Liu, Jun Zhou   +5 more
openaire   +2 more sources

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

Energy status orchestrates YTHDF1 phase separation and tumorigenesis

Cell Reports
Aberrant energy status impacts the initiation and progression of tumorigenesis, although the underlying mechanisms remain poorly understood. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a key sensor of cellular energy stress, is activated to facilitate metabolic adaptation and regulate tumorigenesis.
Haisheng Yu, Jie Shi, Rongrong He, Xue Zhang, Shuchao Ren, Qiushi Chen, Haiou Li, Wenjun Xiong, Yingmeng Yao, Wenjing Song, Yishuang Sun, Chuan He, Xixin Xing, Gaoshan Xu, Xiyong Wang, Yan Ren, Zhipeng Zhou, Zongbi Yi, Jinfang Zhang   +18 more
openaire   +2 more sources

YTHDF1 drives intestinal immune response against bacterial infection [PDF]

, 2020
Abstract Invasion of pathogenic bacteria is a serious threat to intestinal health. Recent emerging evidence has demonstrated that N6-methyladenosine (m 6 A) is closely associated with innate immunity; however, the underlying mechanism remains unclear.
Zong, Xin, Xiao, Xiao, Shen, Bin, Jiang, Qin, Wang, Hong, Lu, Zeqing, Wang, Fengqin, Jing, Minliang, Wang, Yizhen   +8 more
openaire   +1 more source

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response

Genes and Diseases
Severe immune responses regulate the various clinical hepatic injuries, including autoimmune hepatitis and acute viral hepatitis. N6-methyladenosine (m6A) modification is a crucial regulator of immunity and inflammation.
Hao Li, Kailun Yu, Xiandan Zhang, Jiawen Li, Huilong Hu, Xusheng Deng, Siyu Zeng, Xiaoning Dong, Junru Zhao, Yongyou Zhang   +9 more
doaj   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus [PDF]

, 2019
N6-methyladenosine (m6A) is the most abundant internal RNA modification of cellular mRNAs. m6A is recognised by YTH domain-containing proteins, which selectively bind to m6A-decorated RNAs regulating their turnover and translation.
Adams-Cioaba, Alarcón, Alpatov, Anders, Andrews, Antanaviciute, Arguello, Arias, Bailey, Baquero-Pérez, Chen, Chen, Chen, Chen, Conrad, Courtney, Dobin, Dominissini, Du, Edens, Edupuganti, Ewels, Frei dit Frey, Galán, Gao, Gao, Giffin, Gilbert, Gokhale, Guito, Heinrich, Hesser, Hsu, Huang, Hughes, Jain, Jariwala, Jia, Kahles, Karolchik, Kennedy, Kent, Kremmer, Lei, Li, Li, Li, Liao, Liao, Lichinchi, Lichinchi, Liu, Liu, Liu, Liu, Love, Lukac, Luo, Martin, Maurer-Stroh, Mendel, Meyer, Milosevich, Myrick, Nakamura, Patil, Pendleton, Pradeepa, Qin, Renne, Robinson, Schumann, Shi, Sun, Tan, Tirumuru, Tsai, Van Nostrand, Wang, Wang, Wang, Wu, Xiang, Xiao, Xu, Xu, Yang, Ye, Yu, Zheng, Zuker   +90 more
core   +2 more sources