Results 91 to 100 of about 7,941 (215)

The m6A writer:rise of a machine for growing tasks [PDF]

, 2018
The central dogma of molecular biology introduced by Crick describes a linear flow of information from DNA to mRNA to protein. Since then it has become evident that RNA undergoes several maturation steps such as capping, splicing, 3’-end processing and ...
Balacco, Dario Leoanrdo, Soller, Matthias   +1 more
core   +1 more source

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

YTHDF1 Regulates RELA m6A Modification and Activates the NF‐Kappa B Signaling Pathway to Promote the Mechanism of Gastric Cancer

Cancer Medicine
Background Gastric cancer (GC) is an important cause of death. Molecular targeted therapy and immunotherapy are progressing rapidly. It is very important to explore the pathogenesis pathways of GC and provide strong support for its treatment.
Yangyuan Huang, Shihao Liang, Liping Li, Qingyu Zeng, Bin Li   +4 more
doaj   +1 more source

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer

Cancer Management and Research, 2020
Tong Liu,1 Sheng Yang,1 Yan-ping Cheng,1 Xiao-ling Kong,1 Dan-dan Du,1 Xian Wang,1 Yun-fei Bai,2 Li-hong Yin,1 Yue-pu Pu,1 Ge-yu Liang1 1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast ...
Liu T, Yang S, Cheng YP, Kong XL, Du DD, Wang X, Bai YF, Yin LH, Pu YP, Liang GY   +9 more
doaj  

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.

PLoS Biology, 2021
Among over 150 distinct RNA modifications, N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing represent 2 of the most studied modifications on mammalian mRNAs.
Hideki Terajima, Mijia Lu, Linda Zhang, Qi Cui, Yanhong Shi, Jianrong Li, Chuan He   +6 more
doaj   +1 more source

YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR–HIF1α–LHDA Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Breast cancer, a malignant tumour that frightens women, ruthlessly claims the lives of tens of thousands of women around the world every year. However, the mechanism by which YTHDF3 regulates the occurrence and development of breast cancer is still imperfect.
ZiQian Liu, TengFei Jiang, Peng Li, Ke Dong, XiMei Wang, ChenChen Geng, XiaoDong Zhang, Dan Zuo, GuangHui Zhao   +8 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, Volume 13, Issue 20, 9 April 2026.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Decoding COPD-related cognitive impairment: The protective potential of YTHDF1

Cellular Signalling
Cognitive impairment is a significant complication in individuals with chronic obstructive pulmonary disease (COPD), which presents a substantial challenge to future healthcare resource allocation. However, the underlying therapeutic targets and mechanisms remain inadequately understood.
Keke, Lu, Yuanyuan, Qu, Ruohuan, Shi, Chao, Wu, Tao, Xu   +4 more
openaire   +2 more sources

YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production

The Journal of Clinical Investigation
The RNA N6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and progression. We discovered that radiotherapy (RT) increased YTHDF1 expression in dendritic cells (DCs) of PBMCs from patients with cancer, but not in other immune cells ...
Chuangyu Wen, Liangliang Wang, András Piffkó, Dapeng Chen, Xianbin Yu, Katarzyna Zawieracz, Jason Bugno, Kaiting Yang, Emile Z. Naccasha, Fei Ji, Jiaai Wang, Xiaona Huang, Stephen Y. Luo, Lei Tan, Bin Shen, Cheng Luo, Megan E. McNerney, Steven J. Chmura, Ainhoa Arina, Sean Pitroda, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum   +22 more
doaj   +1 more source

M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
ALKBH5‐mediated m6A modification of Igfbp4 mRNA drives fibroblast activation and pathological collagen deposition in upper airway. Abstract Background Laryngotracheal stenosis (LTS) is a fibroproliferative disease of the upper airway characterised by dysregulated extracellular matrix deposition and fibroblast activation.
Jing Wang, Ziwei Liao, Mengrou Xu, Yangyang Zheng, Bin Hu, Qianhui Xia, Hongming Xu   +6 more
wiley   +1 more source