Results 101 to 110 of about 7,941 (215)

m6A reader YTHDF1 inhibits the growth of neuroblastoma in vitro and in vivo

, 2023
Abstract Purpose Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, always leading to an unfavorable prognosis. m6A is the most prevalent modification in eukaryotic RNAs. Util now, the role of N6-methyladenosine (m6A) in NB has not been elucidated.
Jing Deng, Jun Long, Yang Yang, Fengyu Yang   +3 more
openaire   +1 more source

Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Lactic acid metabolism correlates with periodontitis progression. Using machine learning (LASSO and SVM‐RFE) on GSE16134 and GSE173078 datasets, CFI and COQ2 were identified as key genes, with good diagnostic performance (AUC > 0.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin‐mediated proteolysis.
Bijun Zhu, Shi Xu, Mingyue Cheng, Leiying Miao   +3 more
wiley   +1 more source

YTHDF1/RNF7/p27 axis promotes prostate cancer progression

Cell Death & Disease
Abstract Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling pathway, is highly expressed in PCa cancerous tissues and cells, which correlates ...
Yulin Shi, Baiyang Liu, Yong Zhang, Sen Zhao, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng, Cuiping Yang, Yongbin Chen   +11 more
openaire   +3 more sources

FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer

Acta Pharmaceutica
This study aims to investigate the regulatory mechanisms of METTL3, YTHDF1, and the long non-coding RNA FOXD2-AS1 in the proliferation and apoptosis of esophageal cancer, with the goal of providing a basis for molecular diagnosis and targeted therapies ...
Wang Zijin, Liu Xing Chen, Gao Zhen Gya, Shi Wo Da, Wang Wen Cai   +4 more
doaj   +1 more source

A DNA‐Based Binding Assay for the m6A‐RNA Reader Proteins

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report the structure of the m6A‐RNA reader YTHDC2 in the complex with single‐stranded DNA. We provide evidence that the readers exhibit slightly stronger affinity for 6mA‐modified DNA than RNA. Thus, we developed an FP binding assay that uses single‐stranded DNA as probe.
Rajiv Kumar Bedi, Amedeo Caflisch
wiley   +1 more source

YTHDF proteins and m⁶A-RNA clients undergo autophagic turnover during contact inhibition [PDF]

The YTHDF protein family plays a critical role in cancer development by recognizing and regulating the stability of N6-methyladenosine (m6A)-modified RNA. Here, we reveal an autophagy-dependent mechanism controlling YTHDF protein levels.
Bruckmann, A., Brunello, L., Cano-Franco, S., de la Cruz-Thea, B., Dikic, I., Dötsch, V., Feederle, R., Ho-Xuan, H., Hummer, G. , Jacomin, A., Kaiser, S., Khatri, A., Larivera, S., Meister, G., Musri, M., Natali, L., Pfab, A., Prieto-Garcia, C., Prochazka, J., Sanz-Martinez, P., Sedlacek, R., Stolz, A., Stuke, J. , Vicente, A., Wesseling, H.   +24 more
core   +2 more sources

N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression [PDF]

, 2018
The mRNA modification N6-methyladenosine (m6A) is involved in many post- transcriptional regulatory processes including mRNA stability and translational efficiency.
Carraway, K. R., Fry, N.J., Holley, C. L., Ilkayeva, O. R., Law, B. A., Mansfield, Kyle D., NC DOCKS at East Carolina University   +6 more
core   +2 more sources

Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1

Technology in Cancer Research & Treatment, 2020
Objective: Extracellular vesicles (Evs) secreted from cells have been revealed to mediate signal transduction between cells. Nevertheless, the mechanisms through which molecules transported by EVs function remain to be elucidated.
Jianying Zhou MM, Dan Xiao MM, Tingting Qiu MM, Jun Li MM, Zhentian Liu MM   +4 more
doaj   +1 more source

Molecular design of inhibitors for RNA methylation regulating enzymes [PDF]

, 2017
The RNA m6A methylation plays crucial role in various physiological processes and therefore the development of chemical agents controlling this process has large biological and medical importance.
Selberg, Simona
core  

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

Nature Communications
The N6-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blockade treatment. A comprehensive understanding of the molecular mechanisms governing YTHDF1 protein stability is pivotal ...
Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu   +13 more
doaj   +1 more source