Results 121 to 130 of about 7,941 (215)
YTHDF1 gene inhibits epilepsy progression by epigenetic activation of PTEN gene
HeliyonEpilepsy is a common chronic neurological disorder with high prevalence that profoundly affects millions of people worldwide. Inflammatory dysregulation affects central nervous system disorders including epilepsy, and YTHDF1, the most common "reader" of m6A and m6A-binding protein, can attenuate the inflammatory response and activate PTEN, and here we ...
Mingxia Li, Junli Yang, Lixiang Gao
openaire +3 more sources
Erasing “bad memories”: Reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders [PDF]
Dopamine modulates corticostriatal plasticity in both the direct and indirect pathways of the cortico-striato-thalamo-cortical (CSTC) loops. These gradual changes in corticostriatal synaptic strengths produce long-lasting changes in behavioral responses.
LoRocco, Nicholas +4 more
core +1 more source
The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification [PDF]
AIMS: Calcific aortic valve disease (CAVD) is a common heart valve disease with significant clinical consequences. The mechanisms that drive the pathogenesis of CAVD remain to be fully elucidated.
Chen, Guojun +13 more
core +1 more source
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response
Science AdvancesYTH domain–containing family protein 1 (YTHDF1), a reader of N6-methyladenosine (m 6 A), has been implicated in regulating RNA metabolism in the cytosol. Here, we report a role of YTHDF1 within the nucleus in response to genotoxic stress.
Jingyu Hou +5 more
openaire +2 more sources
N6-methyladenosine (m6A) RNA modification in chronic myeloid leukemia: unveiling a novel therapeutic target [PDF]
N6-methyladenosine (m6A), the most prevalent internal mRNA modification, plays a critical role in physiological processes by regulating gene expression through modulation of mRNA metabolism at multiple stages.
Fatica, Alessandro +2 more
core +1 more source
ToxicsBenzo[a]pyrene, as the primary component of air pollutants, has been implicated in the pathogenesis of non-small-cell lung cancer (NSCLC). As an m6A reader that facilitates mRNA translation, YTHDF1 serves as a crucial regulator in tumor progression ...
Siyi Xu +6 more
doaj +1 more source
Guoji laonian yixue zazhiObjective To investigate the effect of YTH domain family protein 1(YTHDF1) on apoptosis and oxidative damage in H9c2 cells under hypoxic reoxygenation(H/R) conditions.
Nielupaier Reyimujiang +6 more
doaj +1 more source
Phenylpyrazoles as Inhibitors of the m6A RNA-Binding Protein YTHDF2. [PDF]
The N6-methyladenosine (m6A) modification, which is the most common RNA modification in eukaryotes, is regulated by the writer methyltransferases, the reader m6A binding proteins, and the eraser demethylases.
Bigler, Katrin +10 more
core +1 more source
YTHDF1’s grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis
Cancer Cell InternationalBackground Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.
Rui-ting Ma +7 more
doaj +1 more source
RNA m 6 A modification, signals for degradation or stabilisation? [PDF]
The RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing
Wei, Guifeng
core +2 more sources