Results 151 to 160 of about 22,865 (199)

Targeting the Mevalonate Pathway in Cancer

Trends in Cancer, 2021
The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol management and cardiovascular health. Thirty years of research have uncovered supportive roles for the mevalonate pathway in numerous cellular processes that support oncogenesis, most recently macropinocytosis. Central to the diverse mechanisms of statin sensitivity
David A Fruman, Dennis Juarez
exaly   +5 more sources

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Mevalonate pathway and male reproductive aging

Molecular Reproduction and Development, 2023
AbstractMale fertility declines with age. The mevalonate pathway, through which cholesterol and nonsteroidal isoprenoids are synthesized, plays key role in metabolic processes and is an essential pathway for cholesterol production and protein prenylation.
Jia‐Le Zhang, Meng Lv, Chao‐Fan Yang, Ying‐Xi Zhu, Chao‐Jun Li   +4 more
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The mevalonate pathway in breast cancer biology

Cancer Letters, 2022
Breast cancer affects one in eight women during their lifetime. Although diagnostic and therapeutic options have improved, recurrence, metastasis, and therapeutic resistance remain clinical challenges, which affect life quality and prognosis. The mevalonate pathway is an essential part of cellular homeostasis by providing a number of essential ...
Andy, Göbel, Romy M, Riffel, Lorenz C, Hofbauer, Tilman D, Rachner   +3 more
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Regulation of the mevalonate pathway

Nature, 1990
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products ...
J L, Goldstein, M S, Brown
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Multienzyme mevalonate pathway bioreactor

Biotechnology and Bioengineering, 2004
AbstractThe five‐carbon metabolic intermediate isopentenyl diphosphate constitutes the basic building block for the biosynthesis of all isoprenoids in all forms of life. Two distinct pathways lead from amphibolic intermediates to isopentenyl diphosphate.
Autumn, Sutherlin, Victor W, Rodwell
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Mevalonate Pathway and Human Cancers

Current Molecular Pharmacology, 2017
Mevalonate (MVA) is synthesized from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by HMG-CoA reductase (HMG-CoAR). MVA is further metabolized to farnesyl pyrophosphate (FPP), a precursor of cholesterol and sterols. FPP is also converted to geranylgeranyl pyrophosphate, and these lipids are used for post-translational modification of proteins that ...
Seyedeh Zahra, Bathaie, Mahboobeh, Ashrafi, Mahshid, Azizian, Fuyuhiko, Tamanoi   +3 more
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Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway

Current Molecular Pharmacology, 2017
Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by pharmaceuticals, commonly referred to as statins, has proven to be an effective and efficient way in reducing cholesterol levels in patients. As a result of this intervention, mevalonate production, formed during cholesterol synthesis, is inhibited.
Alison L, Muller, Darren H, Freed
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Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis

Hormone and Metabolic Research, 2020
Abstract3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme of the mevalonate pathway, which generates cholesterol and non-sterol compounds such as isoprenoid, which are involved in key steps of tumorigenesis such as cell growth and proliferation.
Helena Panteliou, Lima-Valassi, Antonio Marcondes, Lerario, Luciana Ribeiro, Montenegro, Maria Candida Barisson Villares, Fragoso, Madson Queiroz, Almeida, Berenice Bilharinho, Mendonca, Chin Jia, Lin   +6 more
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Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis

Plant Cell Reports, 2013
When one of them was inhibited, the two pathways could compensate with each other to guarantee normal growth. Moreover, the sterol biosynthesis inhibitor miconazole could enhance ginsenoside level.Ginsenosides, a kind of triterpenoid saponins derived from isopentenyl pyrophosphate (IPP), represent the main pharmacologically active constituents of ...
Shoujing, Zhao, Le, Wang, Li, Liu, Yanlong, Liang, Yao, Sun, Jianjun, Wu   +5 more
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Cardioprotection by Farnesol: Role of the Mevalonate Pathway

Cardiovascular Drugs and Therapy, 2013
Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart.Male Wistar rats were treated orally with 0.2, 1, 5, and 50 mg/kg/day farnesol/vehicle for 12 days, respectively. On day 13, the effect of farnesol treatment on cardiac ischemic tolerance and biochemical
Szűcs, Gergő, Murlasits, Zsolt, Török, Szilvia, Kocsis-Fodor, Gabriella, Pálóczi, János, Görbe, Anikó, Csont, Tamás Bálint, Csonka, Csaba, Ferdinandy, Péter   +8 more
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