Results 151 to 160 of about 21,930 (203)

Two Novel and Three Recurrent Mutations in the Mevalonate Pathway Genes in Chinese Patients with Porokeratosis. [PDF]

Clin Cosmet Investig Dermatol
Wang X, Ouyang X, Zhang D, Zhu Y, Wu L, Xiao Z, Yu S, Li W, Li C.   +8 more
europepmc   +1 more source

Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1. [PDF]

Cancer Res Commun
He L, Ioannidis A, Hoffman CJ, Arambula E, Joshi P, Whitelegge J, Liau LM, Kornblum HI, Pajonk F.   +8 more
europepmc   +1 more source

Correction to "Induction of Resistance to Neurotrophic Tropomyosin-Receptor Kinase Inhibitors by HMGCS2 via a Mevalonate Pathway". [PDF]

Cancer Med
europepmc   +1 more source

Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase. [PDF]

J Biol Chem
Avci D, Heidasch R, Costa M, Lüchtenborg C, Kale D, Brügger B, Lemberg MK.   +6 more
europepmc   +1 more source

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Mevalonate Pathway and Human Cancers

Current Molecular Pharmacology, 2017
Mevalonate (MVA) is synthesized from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by HMG-CoA reductase (HMG-CoAR). MVA is further metabolized to farnesyl pyrophosphate (FPP), a precursor of cholesterol and sterols. FPP is also converted to geranylgeranyl pyrophosphate, and these lipids are used for post-translational modification of proteins that ...
Mahboobeh Ashrafi, S Zahra Bathaie, Fuyuhiko Tamanoi   +2 more
exaly   +3 more sources

Mevalonate pathway and male reproductive aging

Molecular Reproduction and Development, 2023
AbstractMale fertility declines with age. The mevalonate pathway, through which cholesterol and nonsteroidal isoprenoids are synthesized, plays key role in metabolic processes and is an essential pathway for cholesterol production and protein prenylation.
Jia‐Le Zhang, Meng Lv, Chao‐Fan Yang, Ying‐Xi Zhu, Chao‐Jun Li   +4 more
openaire   +2 more sources

Regulation of the mevalonate pathway

Nature, 1990
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products ...
J L, Goldstein, M S, Brown
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The mevalonate pathway in breast cancer biology

Cancer Letters, 2022
Breast cancer affects one in eight women during their lifetime. Although diagnostic and therapeutic options have improved, recurrence, metastasis, and therapeutic resistance remain clinical challenges, which affect life quality and prognosis. The mevalonate pathway is an essential part of cellular homeostasis by providing a number of essential ...
Andy, Göbel, Romy M, Riffel, Lorenz C, Hofbauer, Tilman D, Rachner   +3 more
openaire   +2 more sources

Multienzyme mevalonate pathway bioreactor

Biotechnology and Bioengineering, 2004
AbstractThe five‐carbon metabolic intermediate isopentenyl diphosphate constitutes the basic building block for the biosynthesis of all isoprenoids in all forms of life. Two distinct pathways lead from amphibolic intermediates to isopentenyl diphosphate.
Autumn, Sutherlin, Victor W, Rodwell
openaire   +2 more sources