Results 171 to 180 of about 21,930 (203)

Metabolic Engineering of the Mevalonate and Non-Mevalonate Pathways in Tomato

2003
In higher plants isoprenoids have many essential roles e.g. in membrane structure (phytosterols), redox chemistry (plastoquinone) and as antioxidants (carotenoids). Despite their functional and chemical diversity all isoprenoids are biosynthetically related from a common precursor, isopentenyl pyrophosphate (IPP).
E. M. Enfissi, P. D. Fraser, L. M. Lois, A. Boronat, W. Schuch, P. M. Bramley   +5 more
openaire   +1 more source

Biosynthesis of isoprenoids via the non-mevalonate pathway

Cellular and Molecular Life Sciences, 2004
The mevalonate pathway for the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), is known in considerable detail. Only recently, the existence of a second mevalonate-independent pathway for the biosynthesis of IPP and DMAPP was detected in plants and certain eubacteria.
W, Eisenreich, A, Bacher, D, Arigoni, F, Rohdich   +3 more
openaire   +2 more sources

Metabolic control of YAP and TAZ by the mevalonate pathway

Nature Cell Biology, 2014
The YAP and TAZ mediators of the Hippo pathway (hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological properties intersect with cellular metabolism remains unexplained. Here, we show that YAP/TAZ activity is controlled by the SREBP/mevalonate pathway.
Sorrentino G, Ruggeri N, Specchia V, CORDENONSI, MICHELANGELO, Mano M, DUPONT, SIRIO, MANFRIN, ANDREA, Ingallina E, SOMMAGGIO, ROBERTA, Piazza S, ROSATO, ANTONIO, PICCOLO, STEFANO, Del Sal G.   +12 more
openaire   +4 more sources

Targeting the Mevalonate Pathway for Treating Lung Cancer

American Journal of Clinical Oncology, 2019
The mevalonate (MVA) pathway is a key metabolic pathway involved in various important cellular functions. Its downstream products are critical for cell-signaling, cell membrane integrity, protein synthesis, and cellular respiration. The rate-limiting enzyme of this pathway is targeted by statins, a class of medications best known for their lipid ...
Ali, Fatehi Hassanabad, Fady, Mina
openaire   +2 more sources

Targeting mutant p53 through the mevalonate pathway

Nature Cell Biology, 2016
It is well established that mutant forms of the p53 tumour suppressor acquire pro-oncogenic activities. Inhibition of the mevalonate pathway is now shown to promote degradation of select oncogenic mutant p53 proteins, indicating that destabilization of mutant p53 could be a promising therapeutic strategy.
William, Freed-Pastor, Carol, Prives
openaire   +2 more sources

Mevalonate Pathway

2017
Heidrun Karlic, Franz Varga
openaire   +1 more source

The Acetate-Mevalonate Pathway

1981
Margaret L. Vickery, Brian Vickery
openaire   +1 more source

The Mevalonate Pathway in Parasitic Protozoa and Helminths

Experimental Parasitology, 1996
I, Coppens, P J, Courtoy
openaire   +2 more sources

A mevalonate pathway–Hippo pathway connection

Nature Reviews Cancer, 2014
openaire   +1 more source

Cholesterol and beyond - The role of the mevalonate pathway in cancer biology

Biochimica Et Biophysica Acta: Reviews on Cancer, 2020
Tilman Rachner, Martina Rauner, Lorenz C Hofbauer   +2 more
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