A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]
, 2014 Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora +9 more
core +1 more source
Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium [PDF]
, 2019 Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site.
Bodinham, C. +16 more
core +1 more source
Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]
, 2014 Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Callow +30 more
core +3 more sources
MF59®‐adjuvanted vaccines for seasonal and pandemic influenza prophylaxis [PDF]
Influenza and Other Respiratory Viruses, 2008 Abstract Influenza is a major cause of worldwide morbidity and mortality through frequent seasonal epidemics and infrequent pandemics. Morbidity and mortality rates from seasonal influenza are highest in the most frail, such as the elderly, those with underlying chronic conditions and very young children. Antigenic mismatch between strains recommended
Banzhoff, Angelika +5 more
openaire +2 more sources
Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]
, 2017 The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin +8 more
core +2 more sources
Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis [PDF]
European Journal of Immunology, 2001 The mechanisms associated with the immunostimulatory activity of vaccine adjuvants are still poorly understood. We have undertaken a study to determine whether antigen-presenting cell trafficking is modified by administration of the submicron emulsion adjuvant MF59.
M, Dupuis +6 more
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Expert Review of Vaccines, 2019 Background: The higher effectiveness of MF59®-adjuvanted trivalent influenza vaccine (MF59-TIV) vs. nonadjuvanted TIV in preventing influenza-related hospitalizations was found considering few influenza seasons, local and heterogeneous settings.
Francesco Lapi +6 more
doaj +1 more source
Influenza-Impfstoff mit MF59-Adjuvans [PDF]
pharma-kritik, 2008 In vielen Studien vermochte dieser mit einem Squalen-haltigen Adjuvans kombinierte Impfstoff eine stärkere Immunantwort – aber auch mehr unerwünschte Wirkungen – als andere Impfstoffe auszulösen. Ob sich daraus klinische Vorteile ergeben, ist bisher nicht adäquat dokumentiert.nzentwicklung zu erwarten ist.
openaire +1 more source
Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity
Vaccines, 2021 Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li +3 more
doaj +1 more source
Clinical and Developmental Immunology, 2010 We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions.
Vincenzo Baldo +8 more
doaj +1 more source