Results 1 to 10 of about 5,863 (219)

Combining Intramuscular and Intranasal Immunization With the MF59‐Adjuvanted Respiratory Syncytial Virus Pre‐Fusion Protein Subunit Vaccine Induces Potent Humoral and Cellular Immune Responses in Mice [PDF]

MedComm
Respiratory syncytial virus (RSV) ranks as the second leading cause of infant death globally and a significant contributor to morbidity and mortality among adults over 60 years old.
Jie Shi, Hong Lei, Yu Zhang, Chunjun Ye, Xiya Huang, Yishan Lu, Yanyan Liu, Jian Liu, Danyi Ao, Yingqiong Zhou, Jiong Li, Guangwen Lu, Xiangrong Song, Xiawei Wei   +13 more
doaj   +3 more sources

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review [PDF]

Health Science Reports
Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize ...
Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh, Mohsen Ghiasi, Mohammad Rezaei Zadeh Rukerd, Hanieh Mirkamali, Ehsan Shokri   +5 more
doaj   +3 more sources

Enhanced immunogenicity of Staphylococcus aureus IsdE vaccine with SeNPs and BCG adjuvants in mice [PDF]

AMB Express
Staphylococcus aureus is a major cause of nosocomial infections and antimicrobial resistance, emphasizing the urgent need for an effective vaccine. The IsdE protein, a heme-iron transporter, has been identified as a promising antigen target.
Fatemeh Khosravani pour, Setareh Haghighat, Mohammad Hossein Yazdi, Seyed Mehdi Hassanzadeh   +3 more
doaj   +2 more sources

Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype [PDF]

Viruses
Multiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development is essential for pandemic preparedness.
Shuxia Zhang, Jing Tang, Liqi Liu, Hejiang Wei, Li Xin, Kang Xiao, Jinbo Xiao, Jie Dong, Zi Li, Hongyan Bai, Shuaixing Wang, Wenfei Zhu, Lei Yang, Shumei Zou, Dayan Wang   +14 more
doaj   +2 more sources

A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine [PDF]

Frontiers in Immunology
IntroductionReactivation of the varicella-zoster virus (VZV) results in herpes zoster (HZ), which can lead to complications such as postherpetic neuralgia. The commercially available HZ subunit adjuvanted vaccine, Shingrix®, offers significant protection
Zihan Wang, Yingnan Guo, Xin Tang, Ying Sun, Tingting Wu, Hanyu Peng, Cenrong Wang, Weiheng Su, Weiheng Su, Chunlai Jiang, Chunlai Jiang, Chunlai Jiang, Yang Zang, Yaru Quan, Kangwei Xu, Bo Sun, Bo Sun   +16 more
doaj   +2 more sources

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. [PDF]

, 2016
BACKGROUND: In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach.
A Mori, A Seubert, A Wack, AD Luster, AM Krieg, AM Lange, AM Lange, AM Woltman, April R. Torigian, B Sherry, B Zhan, BA Boatin, BF Ardelli, BH Cochran, Bin Zhan, BL Makepeace, BO Duke, C Bourguinat, C Bourguinat, C Ekerfelt, C Van Kooten, CJ Lechner, CR Bozic, D Abraham, D Abraham, D Abraham, D Abraham, D Gordon, David Abraham, DJ Diemert, DL Gordon, DT O'Hagan, EH Johnson, EH Johnson, F Fossiez, F Lu, F Saade, G Davatelis, G Kaplanski, H Hoshino, HC Turner, HC Yip, Henry John McSorley, J Gardon, J Gewiese-Rabsch, J Scheller, J Wu, JA Hess, JD Keenan, JE Bradley, Jessica A. Hess, JF Wamala, JK Eng, JL Foltz, JM Brewer, John B. Patton, JS Kenney, K Awadzi, K Awadzi, KJ Laing, L Beck, L Diawara, L Steeghs, L Zedda, LM Njongmeta, M Kool, M Laan, M Pellegrini, M Trpis, M Winnen, Maria Elena Bottazzi, MH Forouzanfar, MK Spriggs, MY Osei-Atweneboana, N Brattig, N Mahalakshmi, N Petrovsky, N Tsuji, N Tsuji, N Tsuji, Nikolai Petrovsky, P Kohler, PD Cooper, Peter J. Hotez, PJ Hotez, PS Turaga, RL Rubin, RT Fujiwara, S Arumugam, S Bonne-Annee, S Gnjatic, S Lustigman, S Lustigman, S Ramachandran, SA Jones, Sara Lustigman, SD Wolpe, SH Wang, SL Deshmane, T Lalani, Thomas R. Klei, Tingting Zhan, TR Ghimire, U Boehm, U Forssmann, V Schultze, W Yutanawiboonchai, Y Honda-Okubo, YE Kim, YJ Huang   +109 more
core   +23 more sources

PPD in HBsAg vaccine formulation suppressed IFN-γ and IL-4 cytokine responses and induced long-lived humoral immune responses: Results from 220-day monitoring of specific IgG responses [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): HBsAg vaccine is unable to induce Th1 immune responses. Here, immune responses and long-lived IgG responses of HBsAg-Alum, HBsAg-MF59, as well as HBsAg-MF59 were compared when formulated with PPD.
Rayhaneh Mirzaee, Fahimeh Nemati Mansoor, Mina Mirzaee, Bahareh Golkaran, Akbar Khorasani, Niloufar Rashedi, Fatemeh Asgarhalvaei, Mohammad Ali Savoji, Mehdi Mahdavi   +8 more
doaj   +1 more source

A multi-component prime-boost vaccination regimen with a consensus MOMP antigen enhances Chlamydia trachomatis clearance [PDF]

, 2016
The Supplementary Material for this article can be found online at http://journal.frontiersin.org/article/10.3389/fimmu.2016.00162BACKGROUND: A vaccine for Chlamydia trachomatis is of urgent medical need.
Badamchi-Zadeh, A, Barinaga, G, Follman, F, Gomes, JP, Korber, BT, McKay, PF, Nunes, A, Shattock, RJ, Tregoning, JS, Walters, AA   +9 more
core   +10 more sources

Poloxamer-188 Adjuvant Efficiently Maintains Adaptive Immunity of SARS-CoV-2 RBD Subunit Vaccination through Repressing p38MAPK Signaling

Vaccines, 2022
Poloxamer-188 (P188) is a nonionic triblock linear copolymer that can be used as a pharmaceutical excipient because of its amphiphilic nature. This study investigated whether P188 can act as an adjuvant to improve the immunogenicity of severe acute ...
Chao-Hung Chen, Yu-Jen Lin, Li-Ting Cheng, Chien-Hung Lin, Guan-Ming Ke   +4 more
doaj   +1 more source

Evaluating the Immune Response of Recombinant H1N1 Hemagglutinin with MF59 Adjuvant in Animal Model as a Novel Alternative to the Influenza Vaccine

Iranian Journal of Allergy, Asthma and Immunology, 2020
The H1N1 influenza virus is known as a serious pandemic threat across the globe. Vaccination is one of the most effective methods of protection against this virus and the way to reduce the seasonal pandemic risk.
Niloufar Rashedi, Morteza Taghizadeh, Parisa Mohamadynejad, Mehdi Mahdavi, Reza Jalalirad   +4 more
doaj   +1 more source