Results 91 to 100 of about 5,863 (219)

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Release of endogenous danger signals has been found to be a key mechanism of many conventional, broadly used adjuvants. Yet extracellular ATP has so far not been linked to vaccination success. Here we show that ATP release from muscle is crucial for the mechanism of action of the vaccine adjuvant MF59, leading to efficient CD4 T ...
Vono M, Taccone M, Caccin P, Gallotta M, DONVITO, Giovanna, FALZONI, Simonetta, Palmieri E, Pallaoro M, Rappuoli R, DI VIRGILIO, Francesco, De Gregorio E, Montecucco C, Seubert A.   +12 more
openaire   +5 more sources

Cladophora wrightiana Var. Minor Extract Acts as an Adjuvant to Promote Natural Killer Cell Activation by Nasal Influenza Vaccine

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Cladophora wrightiana var. minor (CW) extract, administered as an adjuvant with inactivated influenza virus (iPR8), stimulates both innate and adaptive immune responses. CW enhances NK cell activation, cytotoxic function, and reciprocal crosstalk with dendritic cells, while also promoting CD8+ T cell responses and antigen‐specific IgG production. These
Thi Len Ho, So Yeon Ahn, Eun‐Ju Ko
wiley   +1 more source

Vaccination against fungal diseases: lessons from Candida albicans [PDF]

, 2017
The advances in medicine have achieved great benefits by improving or even eliminating various debilitating diseases or malignancies, expanding life expectancy.
Pais, Célia, Sampaio, Paula
core   +1 more source

Harnessing the Potential of mRNA Vaccines Against Infectious Diseases

Microbial Biotechnology, Volume 18, Issue 8, August 2025.
RNA vaccines are promising because of their flexible design, strong immunogenicity, safety and rapid development. Recent advances have enabled mRNA vaccines to target various pathogens, including viruses such as influenza and HIV, bacteria such as Mycobacteria and Pseudomonas aeruginosa, and parasites such as those causing malaria.
Nouran Rezk, Siobhán McClean
wiley   +1 more source

Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Population aging is a significant demographic change while vaccines are mostly made for children and young adults and their effectiveness might be low in the older population. Age‐associated decline in the immune function (immunosenescence) is a process that may lead to poor vaccine response in the older population.
Shahab Falahi, Amir Abdoli, Azra Kenarkoohi   +2 more
wiley   +1 more source

MF59-adjuvanted influenza vaccine (FLUAD®) elicits higher immune responses than a non-adjuvanted influenza vaccine (Fluzone®): A randomized, multicenter, Phase III pediatric trial in Mexico

Human Vaccines & Immunotherapeutics, 2018
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent ...
Aurelio Cruz-Valdez, Gabriel Valdez-Zapata, Sanjay S. Patel, Flavia V. Castelli, Marcia G. Garcia, Wim T. Jansen, Ashwani Kumar Arora, Esther Heijnen   +7 more
doaj   +1 more source

Vaccines of the future [PDF]

, 2011
Meteorological observations at Bayelva Station in 2016 (level ...
Boike, Julia, Bornemann, Niko, Burke, Eleanor J, Chadburn, Sarah, Gouttevin, Isabelle, Hauber, Ernst, Ippisch, Olaf, Juszak, Inge, Lange, Stephan, Overduin, Pier Paul, Roth, Kurt, Stern, Lielle, Westermann, Sebastian   +12 more
core   +1 more source

Immunological Responses to Tetanus and Influenza Vaccination in Donkeys

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Donkeys are routinely vaccinated with protocols developed for horses, yet species‐specific data on their immune responses are limited. Hypothesis/Objectives We hypothesized that donkeys exhibit robust T‐cell‐mediated immunity and regulatory adaptation after vaccination, comparable to horses.
Maciej Perzyna, Jowita Grzędzicka, Dominika Milczek‐Haduch, Izabela Dąbrowska, Michał Trela, Bartosz Pawliński, Olga Witkowska‐Piłaszewicz   +6 more
wiley   +1 more source

Cumulative clinical experience with MF59-adjuvanted trivalent seasonal influenza vaccine in young children and adults 65 years of age and older

International Journal of Infectious Diseases, 2019
Objective: To assess the long-term safety of MF59-adjuvanted trivalent influenza vaccine (aIIV3; Fluad™) in adults ≥65 years of age. Methods: Data from 36 primary vaccination and 7 re-vaccination Phase I through III trials were analyzed; 7532 subjects ...
Kelly Lindert, Brett Leav, Esther Heijnen, Julia Barrett, Uwe Nicolay   +4 more
doaj   +1 more source

Influenza Vaccination of young children or Antibody Immune Response and Protection after Inactivated Influenza Vaccine in Children – A Literature Review [PDF]

, 2020
Influenza virus infection is a major cause of morbidity and mortality in at risk populations. Children, especially under the age of two, are at an increased risk of complications associated with influenza virus infection.
wall, danielle
core   +1 more source