Structural and antigenic characterization of a novel genotype of Mfa1 fimbriae in Porphyromonas gingivalis [PDF]
Journal of Oral Microbiology, 2023 Background Mfa1 fimbriae of the periodontal pathogen Porphyromonas gingivalis are responsible for biofilm formation and comprise five proteins: Mfa1–5. Two major genotypes, mfa170 and mfa153, encode major fimbrillin.
Yoshiaki Hasegawa +2 more
exaly +6 more sources
Development of monoclonal antibodies against P. gingivalis Mfa1 and their protective capacity in an experimental periodontitis model [PDF]
MSpherePorphyromonas gingivalis (P. gingivalis), a gram-negative, black-pigmented anaerobe, is a major etiological agent and a leading cause of periodontitis. Fimbriae protein Mfa1 is a key virulence factor of P. gingivalis and plays a crucial role in bacterial
Mingya Cao +12 more
exaly +6 more sources
Role of phase-variable Mfa1 fimbriae of Phocaeicola vulgatus in its adhesion and proinflammatory activity toward gut epithelial cells [PDF]
Gut Microbes ReportsBacteroidaceae is a prominent family in the human gut microbiota. The bacteria within this family are characterized by phase variable regulation of diverse surface structures, such as capsular polysaccharides and outer membrane proteins.
Haruyuki Nakayama-Imaohji +2 more
exaly +5 more sources
Diversity analysis of genes encoding Mfa1 fimbrial components in Porphyromonas gingivalis strains
PLoS ONE, 2021 Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is associated with the development of periodontal disease. The genetic diversity in virulence factors, such as adhesive fimbriae, among its strains affects the bacterial pathogenicity.
Yoshiaki Hasegawa, Keiji Nagano
exaly +5 more sources
Japanese Dental Science Review, 2021 In general, the periodontal pathogen Porphyromonas gingivalis expresses distinct FimA and Mfa1 fimbriae. Each of these consists of five FimA–E and five Mfa1–5 proteins encoded by the fim and mfa gene clusters, respectively.
Yoshiaki Hasegawa, Keiji Nagano
exaly +5 more sources
Maturation of the Mfa1 Fimbriae in the Oral Pathogen Porphyromonas gingivalis [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 The Mfa1 fimbriae of the periodontal pathogen Porphyromonas gingivalis are involved in adhesion, including binding to synergistic species in oral biofilms.
Leng Wu +2 more
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Mfa4, an Accessory Protein of Mfa1 Fimbriae, Modulates Fimbrial Biogenesis, Cell Auto-Aggregation, and Biofilm Formation in Porphyromonas gingivalis [PDF]
PLoS ONE, 2015 Porphyromonas gingivalis, a gram-negative obligate anaerobic bacterium, is considered to be a key pathogen in periodontal disease. The bacterium expresses Mfa1 fimbriae, which are composed of polymers of Mfa1.
Yasuo Yoshida +2 more
exaly +5 more sources
High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes fimA, mfa1, hagA, rgpA, and kgp in the Oral Pathogen Porphyromonas gingivalis [PDF]
Pharmaceutics, 2022 Porphyromonas gingivalis (P. gingivalis) is a cornerstone pathogen in the development and progression of periodontal and peri-implant tissue destruction. It is capable of causing dysbiosis of the microbial biofilm and modulation of the host immune system.
Meshal S. Alharbi, Fahad A. Alshehri
doaj +4 more sources
Distribution of Porphyromonas gingivalis fimA and mfa1 fimbrial genotypes in subgingival plaques [PDF]
PeerJ, 2018 Background Strains of periodontal disease-associated bacterium Porphyromonas gingivalis have different pathogenicity, which can be attributed to clonal genetic diversity. P.
Keiji Nagano +4 more
doaj +4 more sources
Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors [PDF]
Journal of Clinical Medicine, 2020 Porphyromonas gingivalis Mfa1 fimbriae are thought to act as adhesion factors and to direct periodontal tissue destruction but their immunomodulatory actions are poorly understood. Here, we investigated the effect of Mfa1 stimulation on the immune and metabolic mechanisms of gingival fibroblasts from periodontal connective tissue.
Akio Mitani +2 more
exaly +3 more sources