Results 141 to 150 of about 16,053 (242)

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy [PDF]

, 2015
Mitochondria provide an essential role in the maintenance of cellular homeostasis with regard to energy generation, redox signaling, and programmed cell death.
Franz, André, Hoppe, Thorsten, Kevei, Éva   +2 more
core   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

REEP5-MFN1/2 tethering in ER-mitochondria crosstalk

Eukaryotic cells utilize membrane contact sites (MCSs) to mediate communication between organelles, with mitochondria-ER contact sites (MERCs) being among the most extensively studied due to their essential roles in maintaining cellular homeostasis. MERCs facilitate critical processes, including lipid biosynthesis, calcium transfer, and mitochondrial ...
openaire   +2 more sources

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Trans-mitochondrial coordination of cristae at regulated membrane junctions [PDF]

, 2015
Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined.
A Kasahara, AA Amchenkova, BH Graham, C Frezza, C Garcia-Perez, CA Mannella, CA Mannella, CR Hackenbrock, CS Lin, D Dikov, DC Jans, DJ Toth, DN Mastronarde, E Braschi, F Ichas, FT Kurz, FT Kurz, G Csordas, G Csordas, J Santo-Domingo, JR Kremer, L Gammaitoni, L Zhou, M Duvert, M Picard, M Picard, M Picard, M Strauss, MV Shornikova, N Khalifat, N Pfanner, P Bhandari, P Pacher, S Cogliati, S Cortassa, SE Darch, SL Archer, T Klecker, T Shutt, VP Skulachev, WL Ng, X Huang, Y Chen, Y Chen, Y Yaniv   +44 more
core   +2 more sources

Nanoceria Nanozyme Attenuates CoCl2‐Induced Oxidative Stress and Mitochondrial Dysfunction in H9c2 Cardiomyoblasts

Nano Select, Volume 7, Issue 4, April 2026.
This study shows that nanoceria protect H9c2 cardiomyoblasts from CoCl2‐induced chemical stress. Nanoceria reduces reactive oxygen species, preserves mitochondrial function, and regulates genes involved in antioxidant defense, intrinsic apoptosis, and inflammation. These findings highlight nanoceria's potential as a redox‐active nanozyme for protecting
Rukhsana Gul, Arwa Bazighifan, Mushtaq A. Dar, Shahid Nawaz, Assim A. Alfadda   +4 more
wiley   +1 more source

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]

, 2018
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core   +2 more sources

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respond in skeletal muscle to support this remarkable resilience.
Audrey Bergouignan, John Noone, Charlotte Brun, Laura Cussonneau, Alexandre Geffroy, Cecile Coudy‐Gandilhon, Isabelle Chery, Alina Lynn Evans, Jon Martin Arnemo, Jonas Kindberg, Guillemette Gauquelin‐Koch, Donal O'Gorman, Etienne Lefai, Fabrice Bertile   +13 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source