Results 161 to 170 of about 11,082 (189)

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [PDF]

Nature, 2017
Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes. Fusion is crucial for the health and physiological functions of mitochondria, including complementation of ...
Yu-Lu Cao, Jian-Xiong Feng, Yu-Jie Li
exaly   +6 more sources

MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival [PDF]

Cell Death and Disease, 2014
AbstractMitochondrial dynamics and quality control have a central role in the maintenance of cellular integrity. Mitochondrial ubiquitin ligase membrane-associated RING-CH (MARCH5) regulates mitochondrial dynamics. Here, we show that mitochondrial adaptation to stress is driven by MARCH5-dependent quality control on acetylated Mfn1. Under mitochondrial
Hyeseong Cho, Kang H, Cho H
exaly   +6 more sources

Some of the next articles are maybe not open access.

Related searches:

Identification and characterization of signal peptide of Mitofusin1 (Mfn1)

Biochemical and Biophysical Research Communications, 2019
Mitofusin1 (Mfn1) mediates outer mitochondrial membrane (OMM) fusion in Opisthokonts. The uncharacterized TM comprises to two helices (namely, the TM1 and TM2) connected by an intermembrane loop. Consistent with previous studies, our results from in silico analyses show that all mitofusins lack N terminal-MTS and the TM may act an internal MTS. We have
Gopala Krishna Aradhyam
exaly   +3 more sources

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation [PDF]

Stem Cell Reports, 2020
Although mitochondrial morphology is well-known for its role in cellular homeostasis, there is surprisingly little knowledge on whether mitochondrial remodeling is required for postnatal germ cell development. In this study, we investigated the functions of MFN1 and MFN2, two GTPases in mitochondrial fusion, during early spermatogenesis.
Jingjing Zhang, Chuanyun Wang, Yuan Wang   +2 more
exaly   +3 more sources

MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells

Neoplasma, 2014
Accumulative evidence has confirmed that, miR-17-92, a typical polycistronic mRNA cluster, was up-regulated in various solid tumors, and play an important role in the occurrence and development progress of tumors. In our study, we detected the six members of miR-17-92 cluster in osteosarcoma cell line, finding that the expression of miR-17 and miR-19b ...
X, Li, F S, Wang, Z Y, Wu, J L, Lin, W B, Lan, J H, Lin   +5 more
exaly   +4 more sources

The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage

Translational Stroke Research, 2022
Neuronal injury following subarachnoid hemorrhage (SAH) has been shown to be associated with mitochondrial dysfunction and oxidative stress. βIIPKC, a subtype of protein kinase C (PKC), accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86.
Yu-Hai Wang, Chun-Hua Hang, Chun-Hua Hang   +2 more
exaly   +3 more sources

The relationship between MFN1 copy number variation and growth traits of beef cattle

Gene, 2022
Copy number variation, as a kind of genetic submicroscopic structural variation, refers to the deletion or repetition of a large segment of genomic DNA, involving a segment size ranging from 50 bp to several MB. Mitochondrial fusion protein (MFN1) gene regulates the fusion of mitochondrial outer membrane in cells and maintains the dynamic needs of ...
Zhi, Yao, Jiaxiao, Li, Zijing, Zhang, Yanan, Chai, Xian, Liu, Jungang, Li, Yajun, Huang, Lijuan, Li, Weihong, Huang, Guojie, Yang, Fuying, Chen, Qiaoting, Shi, Baorui, Ru, Chuzhao, Lei, Eryao, Wang, Yongzhen, Huang   +15 more
openaire   +2 more sources

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming [PDF]

British Journal of Cancer, 2019
Abstract Background Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is still unclear. Methods The mitochondrial fusion protein mitofusin-1 (MFN1 ...
Ze Zhang, Ying Zhu, Xuan Wang
exaly   +3 more sources

Loss of Mfn1 but not Mfn2 enhances adipogenesis

2022
Abstract Objective A biallelic missense mutation in mitofusin 2 ( MFN2 ) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte ...
JP Mann, LC Tabara, A Alvarez-Guaita, L Dong, A Haider, K Lim, P Tandon, JEN Minchin, S O’Rahilly, S Patel, DJ Fazakerley, J Prudent, RK Semple, DB Savage   +13 more
openaire   +1 more source

Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion

Nature Structural & Molecular Biology, 2018
Fusion of the outer mitochondrial membrane is mediated by the dynamin-like GTPase mitofusin (MFN). Here, we determined the structure of the minimal GTPase domain (MGD) of human MFN1 in complex with GDP-BeF3-. The MGD folds into a canonical GTPase fold with an associating four-helix bundle, HB1, and forms a dimer.
Liming Yan, Yuanbo Qi, Xiaofang Huang, Caiting Yu, Lan Lan, Xiangyang Guo, Zihe Rao, Junjie Hu, Zhiyong Lou   +8 more
openaire   +2 more sources