Mitochondrial quality control in health and disease: mechanisms and therapeutic targets. [PDF]
Signal Transduct Target TherCreus A +3 more
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Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy. [PDF]
Clin GenetVolk M +13 more
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Differential Effects of Turmeric Bioactive Compounds on Neuroinflammation and Mitochondrial Homeostasis in Brain Regions in a Rodent Model of Neuropathic Pain. [PDF]
MetabolitesLiu X +5 more
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Isoquercitrin ameliorates chondrocyte dysfunction in osteoarthritis by targeting AKT1-mediated mitochondrial dynamics regulation. [PDF]
PLoS OneDing Y, Wang X, Zong S, Wen Q, Zhang L.
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MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
International Journal of Molecular Sciences, 2021 MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development.
Yuan Wang
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Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization
Cellular Signalling, 2017 Mitochondria are highly dynamic organelles that change size and morphology by fusing together or dividing through fission. In response to cellular cues, signaling cascades may post-translationally modify mitochondria-shaping proteins, which lead to a ...
Hyeseong Cho +2 more
exaly +2 more sources
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [PDF]
Nature, 2017 Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes.
Song Gao, David C Chan
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MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival [PDF]
Cell Death and Disease, 2014 Mitochondrial dynamics and quality control have a central role in the maintenance of cellular integrity. Mitochondrial ubiquitin ligase membrane-associated RING-CH (MARCH5) regulates mitochondrial dynamics.
Hyeseong Cho
exaly +2 more sources
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