Results 171 to 180 of about 11,082 (189)

Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes

Zygote, 2022
SummaryTelomere shortening during oocyte growth and development is related to reproductive ageing and infertility. The main mechanism involved in the maintenance of telomeres is based on telomerase activity, a specialized enzyme complex, which is capable of adding TTAGGG repeats at the ends of the chromosomes.
Mauro Cozzolino, Emre Seli
openaire   +2 more sources

Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Abstract Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions.
Yuting Chen, Jianqing Wu, Weihong Zhao   +2 more
exaly   +3 more sources

Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells

Toxicology in Vitro, 2016
Organotin compounds, such as tributyltin (TBT), are well-known endocrine disruptors. TBT is also known to cause various forms of cytotoxicity, including neurotoxicity and immunotoxicity. However, TBT toxicity has not been identified in normal stem cells.
Shigeru, Yamada, Miki, Asanagi, Naoya, Hirata, Hiroshi, Itagaki, Yuko, Sekino, Yasunari, Kanda   +5 more
openaire   +2 more sources

Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation

Journal of Hazardous Materials
Low testosterone (T) levels are associated with many common diseases, such as obesity, male infertility, depression, and cardiovascular disease. It is well known that environmental cadmium (Cd) exposure can induce T decline, but the exact mechanism remains unclear. We established a murine model in which Cd exposure induced testicular T decline.
Tian-Tian, Wang, Hua-Long, Zhu, Kong-Wen, Ouyang, Hua, Wang, Ye-Xin, Luo, Xin-Mei, Zheng, Qing, Ling, Kai-Wen, Wang, Jin, Zhang, Wei, Chang, Qi, Lu, Yu-Feng, Zhang, Zhi, Yuan, Hao, Li, Yong-Wei, Xiong, Tian, Wei, Hua, Wang   +16 more
openaire   +2 more sources

Modulation of DRP1 and MFN1/2 alters mitochondrial morphology and dynamics in endothelial cells

Physiology
Endothelial microvascular dysfunction is a modifiable risk factor that predicts major adverse cardiac events. Mitochondrial fission and fusion are important regulators of cellular and mitochondrial homeostasis and regulate and we hypothesize that altering mitochondrial fission and fusion may play a critical role in modulating endothelial function ...
Giovanni Quiroz-Delfi, Cristhian Gutierrez Huerta, Erin C. Birch, Andreas M. Beyer, Ph.D   +3 more
openaire   +1 more source

Intratumoral heterogeneity for frameshift mutations of TP53BP1 and MFN1 genes in colorectal cancers

Pathology - Research and Practice, 2018
Eun Ji, Choi, Min Sung, Kim, Nam Jin, Yoo, Sug Hyung, Lee   +3 more
openaire   +2 more sources

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia

Antioxidants, 2023
Ling He, Tong Chen
exaly  

The mitochondrial fusion proteins Mfn1 and Mfn2 are involved in the skin keratinization

Journal of Dermatological Science, 2013
Asuka Suto, Riichiro Abe, Nao Saito, Shotaro Suzuki, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu   +6 more
openaire   +1 more source

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

Redox Biology, 2021
Yuqiong Chen, Dengyue Xu, Pengyu Jia
exaly  

Peer Review #1 of Loss of Mfn1 but not Mfn2 enhances adipogenesis

2023
openaire   +1 more source