Results 151 to 160 of about 16,053 (242)

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease

Frontiers in Cell and Developmental Biology
Mitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang, Ziwei Li, Ying Xu, Chaoqun Xu, Hao Wang, Tao Rui   +5 more
doaj   +1 more source

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily [PDF]

, 2017
Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein-protein interaction domains.
Bandopadhyay, Rina, Biskup, Saskia, Dawson, Ted M., Dawson, Valina L., Glauser, Liliane, Jones, Amy, Moore, Darren J., Moser, Roger, Musso, Alessandra, Stafa, Klodjan, Tsika, Elpida, Xiong, Yulan   +11 more
core  

Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]

, 2019
Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Chan, David C., Graham, Robert L. J., Hess, Sonja, Ladinsky, Mark S., Rojansky, Rebecca, Sweredoski, Michael J., Varuzhanyan, Grigor   +6 more
core  

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

Scientific Reports
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial
Doménica Tarallo, Jennyfer Martínez, Alejandro Leyva, Amy Mónaco, Carolina Perroni, Marcos Tassano, Juan Pablo Gambini, Mónica Cappetta, Rosario Durán, María Moreno, Celia Quijano   +10 more
doaj   +1 more source

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +1 more source

GM2Calc: Precise MSSM prediction for $(g - 2)$ of the muon

, 2015
We present GM2Calc, a public C++ program for the calculation of MSSM contributions to the anomalous magnetic moment of the muon, $(g-2)_\mu$. The code computes $(g-2)_\mu$ precisely, by taking into account the latest two-loop corrections and by ...
Athron, Peter, Bach, Markus, Fargnoli, Helvecio G., Gnendiger, Christoph, Greifenhagen, Robert, Park, Jae-hyeon, Paßehr, Sebastian, Stöckinger, Dominik, Stöckinger-Kim, Hyejung, Voigt, Alexander   +9 more
core   +1 more source

MFn1, MFn2 and OPA1 gene expression of cardiac tissue after high intensity interval training and resveratrol injection in NAFLD rats [PDF]

, 2022
Roeleh Shahini, Ahmad Abdi
openalex   +1 more source

MFN1 is required for follicle development, oocyte maturation, and female fertility [PDF]

Fertility and Sterility, 2018
M. Zhang, M.B. Bener, Z. Jiang, T. Wang, E. Esencan, R. Scott, E. Seli   +6 more
openaire   +1 more source

Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function

Ecotoxicology and Environmental Safety
This research investigated the impact of cyclopiazonic acid (CPA), a mycotoxin, on the function of progenitor Leydig cells (PLCs) in prepubertal male rats, focusing on its potential disruption of mitochondrial integrity through mitofusin 1 (MFN1 ...
Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li   +11 more
doaj   +1 more source

Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration [PDF]

, 2018
Research efforts during the last decade have deciphered the basic molecular mechanisms governing mitochondrial fusion and fission. We now know that in mammalian cells mitochondrial fission is mediated by the large GTPase dynamin-related protein 1 (Drp1 ...
Frank, Stephan, Licci, Maria, Oettinghaus, Björn, Scorrano, Luca   +3 more
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