MHC Class II Presentation in Autoimmunity [PDF]
Cells, 2023 Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina +5 more
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Organizing MHC Class II Presentation [PDF]
Frontiers in Immunology, 2014 Major histocompatibility complex (MHC) class II molecules are ligands for CD4+ T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane
David R Fooksman
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Ligation of MHC Class II Induces PKC-Dependent Clathrin-Mediated Endocytosis of MHC Class II [PDF]
Cells, 2020 In addition to antigen presentation to CD4+ T cells, aggregation of cell surface major histocompatibility complex class II (MHC-II) molecules induces signal transduction in antigen presenting cells that regulate cellular functions. We previously reported
Kento Masaki +6 more
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Evolution of major histocompatibility complex class I and class II genes in the brown bear [PDF]
BMC Evolutionary Biology, 2012 Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna +7 more
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Regulation of MHC class II and CD86 expression by March-I in immunity and disease. [PDF]
Curr Opin Immunol, 2023 Bandola-Simon J, Roche PA.
europepmc +3 more sources
Disruption of hydrogen bonds between major histocompatibility complex class II and the peptide N-terminus is not sufficient to form a human leukocyte antigen-DM receptive state of major histocompatibility complex class II. [PDF]
PLoS ONE, 2013 Peptide presentation by MHC class II is of critical importance to the function of CD4+ T cells. HLA-DM resides in the endosomal pathway and edits the peptide repertoire of newly synthesized MHC class II molecules before they are exported to the cell ...
Monika-Sarah E D Schulze +3 more
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Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Cell Reports, 2021 Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class ...
W. Zac Stephens +13 more
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Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes. [PDF]
PLoS ONE, 2010 Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment.
Kasper Winther Jørgensen +2 more
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Cell Reports, 2023 Summary: Major histocompatibility complex (MHC) class II-reactive CD8+ T cells are found in humans and animals, but little is known about their identity, development, and function.
Xiaojuan Zhou +17 more
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Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
Frontiers in Immunology, 2022 In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented ...
Laura Santambrogio +2 more
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