Results 1 to 10 of about 134,376 (245)

MHC Class II Presentation in Autoimmunity [PDF]

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +4 more sources

Organizing MHC Class II Presentation [PDF]

Frontiers in Immunology, 2014
Major histocompatibility complex (MHC) class II molecules are ligands for CD4+ T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane
David R Fooksman
doaj   +3 more sources

Ligation of MHC Class II Induces PKC-Dependent Clathrin-Mediated Endocytosis of MHC Class II [PDF]

Cells, 2020
In addition to antigen presentation to CD4+ T cells, aggregation of cell surface major histocompatibility complex class II (MHC-II) molecules induces signal transduction in antigen presenting cells that regulate cellular functions. We previously reported
Kento Masaki, Yuhji Hiraki, Hiroka Onishi, Yuka Satoh, Paul A. Roche, Satoshi Tanaka, Kazuyuki Furuta   +6 more
doaj   +4 more sources

Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Cell Reports, 2021
Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class ...
W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round   +13 more
doaj   +1 more source

Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes. [PDF]

PLoS ONE, 2010
Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment.
Kasper Winther Jørgensen, Søren Buus, Morten Nielsen   +2 more
doaj   +1 more source

MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy

Cell Reports, 2023
Summary: Major histocompatibility complex (MHC) class II-reactive CD8+ T cells are found in humans and animals, but little is known about their identity, development, and function.
Xiaojuan Zhou, Xian Jia, Zhe Huang, Chao Yang, Jiali Li, Wangnan Xie, Xiaoyu He, Wei Ying, Chenfeng Liu, Yun Liu, Kunyu Liao, Yazhen Hong, Xiao Lei Chen, Tianying Zhang, Ningshao Xia, Wen-Hsien Liu, Guo Fu, Changchun Xiao   +17 more
doaj   +1 more source

Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome

Frontiers in Immunology, 2022
In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented ...
Laura Santambrogio, Laura Santambrogio, Laura Santambrogio   +2 more
doaj   +1 more source

MHC Class II Tetramers [PDF]

The Journal of Immunology, 2012
Abstract MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II
openaire   +2 more sources

Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle

BMC Evolutionary Biology, 2019
Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias, Ewa Pikus, Dariusz Anderwald   +2 more
doaj   +1 more source

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source