Results 51 to 60 of about 534,915 (376)
The Major Histocompatibility Complex of Old World Camels—A Synopsis
Cells, 2019 This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil +5 more
doaj +1 more source
A central role for HSC70 in regulating antigen trafficking and MHC class II presentation [PDF]
, 2015 Cells rely on multiple intracellular trafficking pathways to capture antigens for proteolysis. The resulting peptides bind to MHC class II molecules to promote CD4(+) T cell recognition.
Blum, Janice S., Deffit, Sarah N.
core +1 more source
Antibody-mediated rejection of arterialised venous allografts is inhibited by immunosuppression in rats. [PDF]
PLoS ONE, 2014 OBJECTIVES AND DESIGN: We determined in a rat model (1) the presence and dynamics of alloantibodies recognizing MHC complexes on quiescent Brown-Norway (BN) splenic cells in the sera of Lewis (LEW) recipients of Brown-Norway iliolumbar vein grafts under ...
Katrin Splith +11 more
doaj +1 more source
Tolerance to MHC class II disparate allografts through genetic modification of bone marrow [PDF]
, 2014 Induction of molecular chimerism through genetic modification of bone marrow is a powerful tool for the induction of tolerance. Here we demonstrate for the first time that expression of an allogeneic MHC class II gene in autologous bone marrow cells ...
Bagley, Jessamyn +4 more
core +1 more source
Designing of interferon-gamma inducing MHC class-II binders
Biology Direct, 2013 BackgroundThe generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis.
Sandeep Kumar Dhanda +2 more
semanticscholar +1 more source
MHC class I and class II structures
Current Opinion in Immunology, 1997 The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides.
openaire +2 more sources
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
BMC Genomics, 2017 Background Bats are an extremely successful group of mammals and possess a variety of unique characteristics, including their ability to co-exist with a diverse range of pathogens.
Justin H. J. Ng +3 more
doaj +1 more source
Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. [PDF]
, 1994 Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to ...
Fanslow, W +3 more
core
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source