Results 101 to 110 of about 7,499 (206)

Platelets modulate NKG2D receptor expression by inducing the release of NKG2DL MICA and MICB from the surface of tumour cell lines.

, 2019
(A,B,C) To examine the role of platelet cloaked tumour cells, platelets and TRAP-induced platelet releasate in regulating NKG2D expression, quantification of NKG2D was performed by flow cytometry of PBMCs in the presence or absence of tumour cells ...
Christopher D. Cluxton (4538440), Orla Sheils (41503), Sharon A. O'Toole (6503714), John J. O'Leary (270631), Cathy Spillane (202526), Clair M. Gardiner (425771)   +5 more
core   +1 more source

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

, 2018
Helping NK cells find their way MICA and MICB proteins can be expressed on tumors and act as “kill me” signals to the immune system.
Kenneth F. May, Rong En Tay, Deng Pan, Daphne Tsoucas, Charles Yoon, Guo-Cheng Yuan, Lucas Ferrari de Andrade, Glenn Dranoff, Yoshinaga Ito, Christopher J. Harvey, Jason W. Pyrdol, Kai W. Wucherpfennig, Soumya Badrinath, Adrienne M. Luoma, Sebastian Kobold, F. Stephen Hodi, Bettina Franz   +16 more
core   +1 more source

Rh159 interferes with intracellular transport of NKG2DL.

, 2016
A) Association with Rh159 prevents intracellular transport of MICB. U373-MICB cells were transduced with adenovectors (MOI = 80) expressing either GFP (AdGFP) or FLAG-tagged Rh159 (AdRh159FL) under control of tetracycline-dependent transactivator ...
Amruta Bhusari (3140676), Abigail B. Ventura (3140688), Louis J. Picker (3140679), Seongkyung Seo (3140691), Scott G. Hansen (843989), Amy W. Hudson (196984), Michael K. Axthelm (359276), Jennie L. Womack (3140682), Christine L. Schneider (196977), Krystal M. Jeffries (3140673), Elizabeth R. Sturgill (3140670), Daniel Malouli (340369), Benjamin J. Burwitz (36131), Jonah B. Sacha (539908), Marieke C. Verweij (357813), Alfred W. Legasse (3140685), Klaus Früh (106067)   +16 more
core   +1 more source

Molecular evalution of MICA and MICB in healthy individuals: quantification of RNA and membrane molecules

Os genes MICA e MICB pertencem ao complexo principal de histocompatibilidade (MHC), considerada a região mais polimórfica do genoma humano. Esses genes codificam proteínas glicosiladas ancoradas à membrana, semelhantes às moléculas de MHC-I, mas que não ...
Ferraz, Ingrid Miranda [UNESP]
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MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury

JCI Insight
MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity.
Harry Pickering, Narges Alipanah-Lechner, Ernie Chen, Dylan Duchen, Holden T. Maecker, Seunghee Kim-Schulze, Ruth R. Montgomery, Chris Cotsapas, Hanno Steen, Florian Krammer, Charles R. Langelier, Ofer Levy, Lindsey R. Baden, Esther Melamed, Lauren I.R. Ehrlich, Grace A. McComsey, Rafick P. Sekaly, Charles B. Cairns, Elias K. Haddad, Albert C. Shaw, David A. Hafler, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, David J. Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H. Kleinstein, Alison D. Augustine, Joann Diray-Arce, Patrice M. Becker, Nadine Rouphael, Matthew C. Altman, Steve Bosinger, Walter Eckalbar, IMPACC Network, Carolyn S. Calfee, Oscar A. Aguilar, Elaine F. Reed, John R. Greenland, Daniel R. Calabrese   +53 more
doaj   +1 more source

MICB Gene [PDF]

, 2020
openaire   +1 more source

Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.

, 2006
In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a ...
Tosh, Kerrie, Adrian V.S. Hill, Ramasamy Pitchappan, Bell, Jordana Tzenova, Hill, Adrian V. S., Kerrie Tosh, Hill, Adrian V S, Muthuswamy Ravikumar, Pitchappan, Ramasamy, Jordana Tzenova Bell, Sarah Meisner, Ravikumar, Muthuswamy, Meisner, Sarah   +12 more
core   +1 more source

MICB wt Allele [PDF]

, 2020
openaire   +1 more source

Alu polymorphism within the MICB gene and association with HLA-B alleles

, 2002
We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly ...
Dunn, D.S., Hui, J., Inoko, H., Oka, A., Martinez, P., Kulski, J.K., Tay, G.K., Romphruk, A.V., Leelayuwat, C.   +8 more
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Regulación génica de los antígenos HLA no clásicos (MICA y MICB. Análisis funcional de su expresión e implicaciones patogénicas de su actividad biológica

, 2006
Los genes MIC y MICB (HLA no clásicos) están localizados en la región MHC de clase I. Son ligandos del receptor activador NKG2D, que se expresa en linfocitos T y en células NK.
Rodríguez Rodero, Sandra
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