Results 81 to 90 of about 7,499 (206)

MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells

Scientific Reports
Natural killer group 2 member D ligands (NKG2DLs) are expressed as stress response proteins in cancer cells. NKG2DLs induce immune cell activation or tumor escape responses, depending on their expression.
Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe, Yuta Baba, Kohei Tajima, Eiji Funayama, Midori Shida, Yuki Maruyama, Aya Sasaki, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Sei Kobayashi, Atsushi Horiike, Noriko Hida, Takehiko Sambe, Koji Nobe, Satoshi Wada, Hitome Kobayashi, Mayumi Tsuji, Shinichi Kobayashi, Takuya Tsunoda, Yoshifumi Kudo, Yuji Kiuchi, Kiyoshi Yoshimura   +29 more
doaj   +1 more source

Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D

Viruses, 2020
The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses.
Mohammad Diab, Dominik Schmiedel, Einat Seidel, Eran Bacharach, Ofer Mandelboim   +4 more
doaj   +1 more source

Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole‐Resistant Strains of Candida spp. and Cryptococcus neoformans

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Addressing the global challenge of antifungal resistance, this work presents a vanillin‐derived Schiff base complexed with zinc (II) (SBZ) with potent activity against fluconazole‐resistant Candida spp. and Cryptococcus neoformans. By activating an apoptotic pathway, ranging from mitochondrial depolarization and oxidative stress to fungal DNA ...
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Daniel Sampaio Rodrigues, Lara Elloyse Almeida Moreira Gomes, Vitória Pessoa de Farias Cabral, Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Jordana Lima Braga, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Thais Lima Ferreira, Elaine Aires de Lima, Ana Carolina Medeiros de Oliveira, Hélio Vitoriano Nobre Júnior   +14 more
wiley   +1 more source

Temozolomide Resistance is Associated with Upregulated MICB mRNA Expression and Protein Secretion in Human Glioblastoma Cells [PDF]

BACKGROUND: Standard treatment for glioblastoma multiforme (GBM) chemotherapy with temozolomide (TMZ) is often limited by chemoresistance, which is correlated with cancer immune evasion caused by the dysregulation of natural killer group 2 member D ...
Iswanti, Febriana Catur, Kawengian, Kevin Johanes, Wanandi, Septelia Inawati, Alpaddli, Remizar   +3 more
core   +1 more source

MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer [PDF]

Iranian Journal of Immunology, 2016
Background: The role of Matrix Metalloproteinase 9 (MMP9) in tumor invasion and progression is prominent. A single nucleotide polymorphism (SNP) in the promoter region of MMP9 (-1562 C/T) increases the transcription and expression of this gene.
Mohammad Hasan Bargostavan, Gilda Eslami, Nasrin Esfandiari, Ali Shams Shahemabadi   +3 more
doaj  

Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity.

PLoS ONE, 2015
BackgroundEndometriosis is a benign gynaecological disease. Abundant bulk of evidence suggests that patients with endometriosis have an immunity dysfunction that enables ectopic endometrial cells to implant and proliferate.
Iñaki González-Foruria, Pietro Santulli, Sandrine Chouzenoux, Francisco Carmona, Frédéric Batteux, Charles Chapron   +5 more
doaj   +1 more source

Functional Characterisation and Analysis of the Soluble NKG2D Ligand Repertoire Detected in Umbilical Cord Blood Plasma

Frontiers in Immunology, 2018
We previously reported that cord blood plasma (CBP) contains significantly more soluble NKG2D ligands (sNKG2DLs), such as sMICB and sULBP1, than healthy adult plasma.
Steven T. Cox, Steven T. Cox, Robert Danby, Robert Danby, Diana Hernandez, Diana Hernandez, J. Alejandro Madrigal, J. Alejandro Madrigal, Aurore Saudemont, Aurore Saudemont   +9 more
doaj   +1 more source

Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment [PDF]

, 2015
Background: The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases including cancer.
Velavan, Thirumalaisamy P., Son, Ho Anh, Do Quyet, Bui Tien Sy, Peter G Kremsner, Song, Le Huu, Cuong, Bui Khac, Kremsner, Peter G., Bui Khac Cuong, Vu Quoc Binh, Thirumalaisamy P Velavan, Quyet, Do, Toan, Nguyen Linh, Tong, Hoang Van, Binh, Vu Quoc, Hoan, Nghiem Xuan, Nghiem Xuan Hoan, Ho Anh Son, Bock, Thomas, Nguyen Linh Toan, Hoang Van Tong, Sy, Bui Tien, Le Huu Song, Claus Thomas Bock   +23 more
core   +2 more sources

Characterization and transcription of non-classical class I major histocompatibility complex (MHC) genes in buffaloes [PDF]

Brazilian Journal of Biology
The objective of the present study was to characterize non-classical class I major histocompatibility complex (MHC) genes in buffaloes and evaluate the expression of these genes in different tissue components of the placenta of buffaloes during pregnancy
L. S. S. Ribeiro, D. R. Xavier, T. D. S. Rosa, A. A. Macêdo, D. L. S. Ribeiro, F. S. Paz, E. M. C. Silva, A. I. L. Ribeiro, J. R. S. Torres-Júnior, R. B. Viana, L. Tchaicka, A. V. Carvalho-Neta   +11 more
doaj   +1 more source

Evaluation of MICA and MICB Genes in Individuals of Indian Origin by Next Generation Sequencing

Major Histocompatibility Complex class I chain‐related genes; MICA and MICB are highly polymorphic genes which can differentially influence disease vulnerability and histocompatibility for transplantation, functionally.
Gaurav Sharma, Disha Agarwal, Pankaj Malhotra, Alka Khadwal   +3 more
core   +1 more source