Results 71 to 80 of about 7,499 (206)

Identification of oxidative stress-related biomarkers in uterine leiomyoma: a transcriptome-combined Mendelian randomization analysis

Frontiers in Endocrinology
BackgroundOxidative stress has been implicated in the pathogenesis of uterine leiomyoma (ULM) with an increasing incidence. This study aimed to identify potential oxidative stress-related biomarkers in ULM using transcriptome data integrated with ...
Yingxiao Li, Haoyue Chen, Hao Zhang, Zhaochen Lin, Liang Song, Chuanliang Zhao, Chuanliang Zhao   +6 more
doaj   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

New biomarkers for antenatal infection: MICA and MICB gene expression in preterm babies

, 2017
PubMedID: 28969449The human major histocompatibility complex class I chain-related gene A and B (MICA and MICB) is one of the genes in chromosome 6. As MIC expression is inducible by heat, viral infection, inflammation and DNA damage, the molecules have ...
Atay A., Akçalı M., Yıldız Ş.M., Özlü F., Yapıcıoğlu Yıldızdaş H., Gözet Y., Ferda Özlü, Asena Atay, Mustafa Akçalı, Hacer Yapıcıoğlu Yıldızdaş, Yusuf Gözet, Şule Menziletoğlu Yıldız   +11 more
core   +1 more source

Downregulation and/or Release of NKG2D Ligands as Immune Evasion Strategy of Human Neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2004
Neuroblastoma (NB) is a pediatric extracranial tumor characterized by downregulation of human leukocyte antigen class I and defects of the antigen processing machinery, two features that make it an appropriate target for natural killer (NK)-mediated ...
Lizzia Raffaghello, Ignazia Prigione, Irma Airoldi, Marta Camoriano, Isabella Levreri, Claudio Gambini, Daniela Pende, Alexander Steinle, Soldano Ferrone, Vito Pistoia   +9 more
doaj   +1 more source

Extracellular Vesicles in Acute Myeloid Leukemia: Opportunities and Obstacles for Therapeutic Advancement

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley   +1 more source

Globally learning gene regulatory networks based on hidden atomic regulators from transcriptomic big data

BMC Genomics, 2020
Background Genes are regulated by various types of regulators and most of them are still unknown or unobserved. Current gene regulatory networks (GRNs) reverse engineering methods often neglect the unknown regulators and infer regulatory relationships in
Ming Shi, Sheng Tan, Xin-Ping Xie, Ao Li, Wulin Yang, Tao Zhu, Hong-Qiang Wang   +6 more
doaj   +1 more source

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

Multiancestry and Multitrait GWAS Meta‐Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
This study integrated GWAS data for schizophrenia from European (PGC, FinnGen, iPSYCH) and East Asian cohorts with GWAS of chronic pulmonary diseases (COPD, asthma, ILD, pneumonia) and lung function traits, alongside transcriptomic and proteomic datasets (GEO, GTEx, CommonMind, pQTL).
Abudusalamu Ayoufu, Ayinigeer Abulimiti, Wusimanjiang Aierken, ZhouBin Wei, XueCheng Wang, HaiFeng Wang, Liang Zhao   +6 more
wiley   +1 more source

MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. [PDF]

Rationale: Acute lung injury (ALI) carries a high risk of mortality but has no established pharmacologic therapy. We previously found that experimental ALI occurs through natural killer (NK) cell NKG2D receptor activation and that the cognate human ...
Raymond, Wilfred, Ware, Lorraine B, Gonzalez-Hinojosa, Maria DR, Tsao, Tasha, Qualls, Anita E, Obeidalla, Sarah, Kukreja, Jasleen, Kerchberger, V Eric, Aguilar, Oscar A, Hays, Steven R, Calabrese, Daniel R, Looney, Mark R, Christie, Jason, Singer, Jonathan P, Shaver, Ciara M, Lanier, Lewis L, Golden, Jeffrey A, Diamond, Joshua M, Greenland, John R   +18 more
core   +1 more source

Fig. 1e

, 2021
Different subtypes of breast cancer was scored based on proportion of MICA/MICB positive cells. (score 0 (no MICA/MICB expression), score 1 (< 10%), score 2 (10% to 50%) score 3 (51 to 80%) and score 4 (>80%) tumor cells expressing MICA/MICB)
Manel Kraiem (10653344)
core   +1 more source