Results 171 to 180 of about 7,499 (206)

MICA and MICB microsatellite alleles in HLA extended haplotypes

European Journal of Immunogenetics, 2001
SummaryThe present study is a contribution to the definition of the linkage disequilibrium relationship of MICA and MICB with adjacent loci and to the characterization of extended HLA haplotypes. These issues are of importance for the identification of disease associations and for a better definition of donor–recipient compatibility in bone‐marrow ...
BOLOGNESI E, D'ALFONSO, Sandra, ROLANDO V, FASANO E, PRATICÒ L, MOMIGLIANO, Patricia   +5 more
openaire   +3 more sources

Characterization of a novel MICB variant in an individual from the Chinese Uyghur population, MICB*005:09, by cloning and sequencing

International Journal of Immunogenetics, 2018
SummaryA new allelic variant in MICB*005 lineage, MICB*005:09, has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR‐sequence‐based typing (Sanger sequencing) and confirmed by cloning and sequencing.
Mikrban Tursun, ZhenFang Wang, WenTao Guo, Ayshamgul Hasim, Wei Tian   +4 more
openaire   +2 more sources

Association of MICA and MICB alleles with symptomatic dengue infection

Human Immunology, 2011
Dengue viruses (DV) are one of the most important arthropod-borne viral diseases in the developing world. DV can cause syndromes that are either self-limiting or severe. Allelic variants of human leukocyte antigen (HLA) genes have been demonstrated to be associated with disease susceptibility.
Gissel, García, Florencia, del Puerto, Ana B, Pérez, Beatriz, Sierra, Eglys, Aguirre, Mihoko, Kikuchi, Lizet, Sánchez, Kenji, Hirayama, María G, Guzmán   +8 more
openaire   +2 more sources

Full‐Length Sequence Characterisation of the Novel MICB  Null Allele, MICB*068N

HLA
ABSTRACT The novel null allele MICB*068N was identified by full‐length MICB genotyping.
J. A. M. Lucas, S. Akter, J. Robinson, S. G. E. Marsh, N. P. Mayor   +4 more
openaire   +2 more sources

MICA and MICB Genes: Can the Enigma of Their Polymorphism Be Resolved?

Trends in Immunology, 2001
The human MHC class I chain-related genes (MICA and MICB) are located within the HLA class I region of chromosome 6. Their organization, expression and products differ considerably from classical HLA class I genes. MIC proteins are considered to be markers of "stress" in the epithelia, and act as ligands for cells expressing a common activatory natural
H A Stephens, Henry A F Stephens
exaly   +3 more sources

Characterization of 3′untranslated region (3′UTR) of the MICB gene

Human Immunology, 2013
In this study, the 3'untranslated region (3'UTR) of MHC class I chain-related gene B (MICB) were investigated in 104 healthy, unrelated Han individuals recruited from northern China, using PCR-sequencing method. Seven polymorphic sites were detected including a 2-bp deletion/insertion, a 6-bp deletion/insertion and 5 SNPs. Seven different 3'UTR alleles
FengHua, Pan, XueXiang, Liu, JuFang, Huang, Wei, Tian   +3 more
openaire   +2 more sources

MICA, MICB and C1_4_1 polymorphism in Crohn’s disease and ulcerative colitis

Tissue Antigens, 2001
Abstract:MICA and MICB belong to a multicopy gene family located in the major histocompatibility complex (MHC) class I region near the HLA‐B gene. They encode for MHC class I molecules, which are induced by stress factors like infection, heat shock or neoplastic transformation and which are mainly expressed on gastrointestinal epithelium.
J, Glas, K, Martin, G, Brünnler, R, Kopp, C, Folwaczny, E H, Weiss, E D, Albert   +6 more
openaire   +2 more sources

The nucleotide diversity of MICA and MICB suggests the effect of overdominant selection

Tissue Antigens, 2001
Abstract: The major histocompatibility complex (MHC) class I‐related molecules A and B (MICA and MICB) are stress‐inducible cell surface antigens that are recognized by immunocytes bearing the receptor NKG2D. In our study we estimated the average number of synonymous (πs) and nonsynonymous nucleotide substitutions (πa) per site in exons 2–4 of MICA and
H A, Elsner, M, Schroeder, R, Blasczyk
openaire   +2 more sources

Linkage disequilibria between HLA‐B, C1_4_1, MICA and MICB

Tissue Antigens, 2001
Abstract:The polymorphisms of MICA exon 5 (5 alleles), MICB intron 1 (13 alleles), C1_4_1 (6 alleles), HLA‐B (29 alleles) and HLA‐A (15 alleles) were investigated in a healthy German population. Sequencing was performed for the MICB alleles CA14, CA15, CA17, CA23 and CA26 isolated from different cell lines.
J, Glas, A I, Werner, G, Brünnler, K, Witter, S, Scholz, E H, Weiss, E D, Albert   +6 more
openaire   +2 more sources

Distribution of MICB diversity in the Zhejiang Han population: PCR sequence-based typing for exons 2–6 and identification of five novel MICB alleles

Immunogenetics, 2013
The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches. In the present study, a novel polymerase chain reaction sequence-based typing (PCR-SBT) method was established for the genotyping of MICB exons 2-
Yanling, Ying, Yanmin, He, Sudan, Tao, Zhedong, Han, Wei, Wang, Nanying, Chen, Junjun, He, Wei, Zhang, Ji, He, Faming, Zhu, Hangjun, Lv   +10 more
openaire   +2 more sources