Results 91 to 100 of about 20,210 (217)
Variations in the germinal center response revealed by genetically diverse mouse strains
Immunology &Cell Biology, Volume 102, Issue 10, Page 935-948, November‐December 2024.In this study, we investigated the impact of genetic variation on the germinal center response. Using a panel of genetically divergent strains, we uncover an important impact of genetics on the number, size and cellular composition of germinal centers, both at steady state and after immune challenge.
Anne‐Marie Aubin +7 more
wiley +1 more source
Skeletal Phenotyping of Period‐1‐Deficient Melatonin‐Proficient Mice
Journal of Pineal Research, Volume 76, Issue 8, November 2024.ABSTRACT In mice, variability in adult bone size and density has been observed among common inbred strains. Also, in the group of genes regulating circadian rhythmicity in mice, so called clock genes, changes in body size and skeletal parameters have been noted in knockout mice.
Olaf Bahlmann +6 more
wiley +1 more source
Working with Miraculous Mice: Mus musculus as a Model Organism
Current Protocols, Volume 4, Issue 10, October 2024.Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley +4 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1992 Different patterns of cutaneous leishmaniasis can be induced when a challenge of alike dose of Leishmania amazonensis amastigotes in various inbred strains was applied.
Kátia da Silva Calabrese +1 more
doaj +1 more source
Frontiers in Neuroscience, 2020 We measured indirect calorimetry and activity parameters, VO2 and VCO2 to extract respiratory exchange ratio (RER) and energy expenditure in both sexes of 30 inbred mouse strains of 6 genetic families at 9–13 weeks during one photophase and the ...
Christine König +6 more
doaj +1 more source
Cytometry Part A, Volume 105, Issue 9, Page 659-665, September 2024.Abstract This panel was designed to characterize the immune cell landscape in the mouse tumor microenvironment as well as mouse lymphoid tissues (e.g., spleen). As an example, using the MC‐38 mouse syngeneic tumor model, we demonstrated that we could measure the frequency and characterize the functional status of CD4 T cells, CD8 T cells, regulatory T ...
Gabriel DeNiro +8 more
wiley +1 more source
Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. [PDF]
, 1985 Mixed allogeneically reconstituted mice (B10 + B10.D2----B10) that specifically accept B10.D2 tail skin allografts were examined for in vivo and in vitro immunocompetence, patterns of hematopoietic repopulation, and in vitro reactivity.
Barbieri, SA +4 more
core
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]
, 1994 Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM +4 more
core +1 more source
L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage [PDF]
, 2002 Objective: To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage. Background. Depressed wound immune function contributes to an increased incidence of wound infections following hemorrhage ...
Angele, Martin K. +7 more
core +1 more source
Neural Plasticity, 2017 The genetic background of mice has various influences on the efficacy of physical exercise, as well as adult neurogenesis in the hippocampus. In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill ...
Jong Whi Kim +7 more
doaj +1 more source