Results 81 to 90 of about 20,210 (217)

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. [PDF]

PLoS ONE, 2013
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved.
Elisabeth Kemter, Petra Prückl, Birgit Rathkolb, Kateryna Micklich, Thure Adler, Lore Becker, Johannes Beckers, Dirk H Busch, Alexander A Götz, Wolfgang Hans, Marion Horsch, Boris Ivandic, Martin Klingenspor, Thomas Klopstock, Jan Rozman, Anja Schrewe, Holger Schulz, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabé de Angelis, Eckhard Wolf, Bernhard Aigner   +21 more
doaj   +1 more source

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health‐related outcomes. Our objective was the determination of the transcriptomic signature of physical
Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel   +16 more
wiley   +1 more source

TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiology has not been studied.
Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin   +4 more
wiley   +1 more source

Comparison of the behaviour of three strains of laboratory mice in the climbing test

Animal Welfare, Etológia és Tartástechnológia
In our study, we tested three commonly used strains of laboratory mice in a simple behavioural test. In the climbing test, we looked at the time of the first climb and the number of climbs of the different strains during the 5-minute test time, depending
Henrietta Kinga Török, Boróka Bárdos, Orsolya Ivett Hoffmann   +2 more
doaj   +1 more source

Comparative effects of vasectomy surgery and buprenorphine treatment on faecal corticosterone concentrations and behaviour assessed by manual and automated analysis methods in C57 and C3H mice.

PLoS ONE, 2013
Establishing effective cage-side pain assessment methods is essential if post-surgical pain is to be controlled effectively in laboratory animals. Changes to overall activity levels are the most common methods of assessment, but may not be the most ...
Sian Wright-Williams, Paul A Flecknell, Johnny V Roughan   +2 more
doaj   +1 more source

In vitro studies on tumor-specific immunity by using C3H mammary cancer-A cells. I. Inhibitory effect of lymph-node cells from the tumor bearing isologous C3H mouse on the proliferation of the tumor cells [PDF]

, 1966
As a link in the series of studies on tumor-specific immunity, in vitro inhibitory effect of sensitized isologous lymph-node cells on the proliferation of C3H mammary cancer was studied.
Satoh, Katuaki
core   +1 more source

The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis

Aging Cell, Volume 24, Issue 2, February 2025.
We conducted a meta‐analysis to investigate the impact of cysteine supplementation on lifespan in mice, nematodes, and fruit flies. Positive effects were observed in C. elegans, transgenic flies, and disease model mice, but not in wild‐type flies and wild‐type mice.
Yue Ma, Mengqi Chen, Kaiyao Huang, Wakam Chang   +3 more
wiley   +1 more source

Caracterização biológica comparativa das cepas Berenice e Berenice-78 de Trypanosoma cruzi isoladas da mesma paciente em diferentes períodos Comparative biological characterization of Berenice and Berenice-78 strains of Trypanosoma cruzi isolated from the same patient in different periods

Memorias do Instituto Oswaldo Cruz, 1986
A amostra Berenice-78 de T. cruzi recém-isolada apresentou características bem distintas da cepa Berenice isolada há 16 anos da mesma paciente. Foram verificadas sua alta infectividade e baixa virulência para camundongos C3H isogênicos que sobreviveram à
M. Lana, Cléa de Andrade Chiari
doaj   +1 more source

Inhibition of in vitro fertilizing capacity of cryopreserved mouse sperm by factors released by damaged sperm, and stimulation by glutathione. [PDF]

PLoS ONE, 2010
BACKGROUND: In vitro fertilization (IVF) of eggs by frozen and thawed C57BL/6J mouse sperm is inhibited by dead sperm and enhanced by preincubation of the sperm in calcium-free medium.
Mary L Bath
doaj   +1 more source

Characterization of murine T-cell epitopes on mycobacterial DNA-binding protein 1 (MDP1) using DNA vaccination [PDF]

, 2010
Mycobacterial DNA-binding protein 1 (MDP1) is a major protein antigen in mycobacteria and induces protective immunity against Mycobacterium tuberculosis infection in mice.
Koide, Yukio, Matsumoto, Makoto, Matsumoto, Sohkichi, Nagata, Toshi, Suzuki, Daisuke, Tsujimura, Kunio   +5 more
core   +2 more sources