Results 61 to 70 of about 15,270 (172)

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. [PDF]

PLoS ONE, 2013
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved.
Elisabeth Kemter, Petra Prückl, Birgit Rathkolb, Kateryna Micklich, Thure Adler, Lore Becker, Johannes Beckers, Dirk H Busch, Alexander A Götz, Wolfgang Hans, Marion Horsch, Boris Ivandic, Martin Klingenspor, Thomas Klopstock, Jan Rozman, Anja Schrewe, Holger Schulz, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabé de Angelis, Eckhard Wolf, Bernhard Aigner   +21 more
doaj   +1 more source

Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER

Physiological Reports, Volume 13, Issue 19, October 2025.
Study and results overview. Abstract Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain‐specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory ...
N. Amiri, H. Zhang, R. McMillan, R. W. Grange, J. C. Drake   +4 more
wiley   +1 more source

Comparison of the behaviour of three strains of laboratory mice in the climbing test

Animal Welfare, Etológia és Tartástechnológia
In our study, we tested three commonly used strains of laboratory mice in a simple behavioural test. In the climbing test, we looked at the time of the first climb and the number of climbs of the different strains during the 5-minute test time, depending
Henrietta Kinga Török, Boróka Bárdos, Orsolya Ivett Hoffmann   +2 more
doaj   +1 more source

Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice

Molecular vision, 2016
Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical studies often rely on the retinal degeneration 1 (rd1 or Pde6b(rd1)) retinitis pigmentosa (RP) mouse model. The rd1 founder mutation is present in more than 100 actively used mouse lines.
Michiel, van Wyk, Sabine, Schneider, Sonja, Kleinlogel   +2 more
openaire   +2 more sources

Comparative effects of vasectomy surgery and buprenorphine treatment on faecal corticosterone concentrations and behaviour assessed by manual and automated analysis methods in C57 and C3H mice.

PLoS ONE, 2013
Establishing effective cage-side pain assessment methods is essential if post-surgical pain is to be controlled effectively in laboratory animals. Changes to overall activity levels are the most common methods of assessment, but may not be the most ...
Sian Wright-Williams, Paul A Flecknell, Johnny V Roughan   +2 more
doaj   +1 more source

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health‐related outcomes. Our objective was the determination of the transcriptomic signature of physical
Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel   +16 more
wiley   +1 more source

Caracterização biológica comparativa das cepas Berenice e Berenice-78 de Trypanosoma cruzi isoladas da mesma paciente em diferentes períodos Comparative biological characterization of Berenice and Berenice-78 strains of Trypanosoma cruzi isolated from the same patient in different periods

Memorias do Instituto Oswaldo Cruz, 1986
A amostra Berenice-78 de T. cruzi recém-isolada apresentou características bem distintas da cepa Berenice isolada há 16 anos da mesma paciente. Foram verificadas sua alta infectividade e baixa virulência para camundongos C3H isogênicos que sobreviveram à
M. Lana, Cléa de Andrade Chiari
doaj   +1 more source

TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiology has not been studied.
Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin   +4 more
wiley   +1 more source

The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis

Aging Cell, Volume 24, Issue 2, February 2025.
We conducted a meta‐analysis to investigate the impact of cysteine supplementation on lifespan in mice, nematodes, and fruit flies. Positive effects were observed in C. elegans, transgenic flies, and disease model mice, but not in wild‐type flies and wild‐type mice.
Yue Ma, Mengqi Chen, Kaiyao Huang, Wakam Chang   +3 more
wiley   +1 more source

Enhancement of Leishmania amazonensis infection in BCG non-responder mice by BCG-antigen specific vaccine

Memorias do Instituto Oswaldo Cruz, 1992
Different patterns of cutaneous leishmaniasis can be induced when a challenge of alike dose of Leishmania amazonensis amastigotes in various inbred strains was applied.
Kátia da Silva Calabrese, Sylvio Celso Gonçalves da Costa   +1 more
doaj   +1 more source