Results 51 to 60 of about 15,270 (172)

Experimental Models and Molecular Pathogenesis: An Integrated Review of Alopecia

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
A disconnect between mechanistic discovery and the physiological relevance of preclinical models fundamentally hampers the development of effective therapies for alopecia. This review critically bridges the pathogenic underpinnings of major hair loss disorders—androgenetic alopecia, alopecia areata, telogen effluvium, and chemotherapy‐induced anagen ...
Yuexin Fu, Xiaoying Dai, Zhanrui Li, Zheng Li, Jingjie Li, Suraiya Saleem   +5 more
wiley   +1 more source

Genetic factors at the enterocyte level account for variations inintestinal cholesterol absorption efficiency among inbred strains of mice1

Journal of Lipid Research, 2001
Interindividual and interstrain variations in cholesterol absorptionefficiency occur in humans and animals. We investigated physiological biliaryand small intestinal factors that might determine variations in cholesterolabsorption efficiency among inbred
David Q-H. Wang, Beverly Paigen, Martin C. Carey   +2 more
doaj   +1 more source

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. [PDF]

PLoS ONE, 2016
Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project.
Sudhir Kumar, Birgit Rathkolb, Elisabeth Kemter, Sibylle Sabrautzki, Dian Michel, Thure Adler, Lore Becker, Johannes Beckers, Dirk H Busch, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Ingrid Liliana Vargas Panesso, Alexandra Vernaleken, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Eckhard Wolf, Bernhard Aigner   +24 more
doaj   +1 more source

Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice [PDF]

Infection and Immunity, 1990
We tested the possibility that two phenotypic traits, defective activation of macrophage antileishmanial activities and susceptibility to infection with Leishmania major, were controlled by the same gene. We used P/J (susceptible) and C3H/HeN (resistant) mice to breed F1, backcross (Bx), and F2 mice that were tested individually for both traits, each ...
A H, Fortier, A, Tong, C A, Nacy
openaire   +2 more sources

Adipocyte‐specific ablation of plakoglobin in mice does not affect adiposity but results in sexual‐dimorphic effects on weight gain

Physiological Reports, Volume 13, Issue 24, December 2025.
Abstract The main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β‐catenin homolog, plakoglobin, in the regulation of ...
Frederic Abou Azar, Alexis Vivoli, Arturo I. Machuca‐Parra, Frédéric Paré, Mete Civelek, Weinian Shou, Gareth E. Lim   +6 more
wiley   +1 more source

Caracterização biológica de clones das cepas Y, CL e MR de Trypanosoma cruzi em camundongos C3H isogênicos Biological characterization of Trypanosoma cruzi clones from Y, CL and MR strains in C3H inbred mice

Memorias do Instituto Oswaldo Cruz, 1988
Dez clones isolados das cepas Y, CL e MR foram caracterizados segundo infectividade das culturas, curvas de parasitemia, polimorfismo e mortalidade em camundongos C3H isogênicos.
S. Marques de Araújo, E. Chiari
doaj   +1 more source

Biological sex modulates lung injury severity in adolescent mice exposed to short‐term aerosolized vitamin E acetate

Physiological Reports, Volume 13, Issue 23, December 2025.
Abstract The E‐cigarette or Vaping product‐Associated Lung Injury (EVALI) causes severe acute respiratory failure and, in some cases, death. Most cases are linked to tetrahydrocannabinol‐containing e‐cigarette products adulterated with vitamin E acetate.
Michelle J. Lim, Xiaohan Li, Jihau Yu, Heesun Kim, Delaney Stevenson, Negin Esfandiari, Lillian N. Tran, Tran B. Nguyen, Jocelyn A. Livezey, Christoph F. A. Vogel, Eliot R. Spindel, Timothy E. Albertson, Michael A. Matthay, Kent E. Pinkerton   +13 more
wiley   +1 more source

Cranial bone morphometric study among mouse strains

BMC Evolutionary Biology, 2008
Background Little is known about the molecular mechanism which regulates how the whole cranium is shaped. Mouse models currently available for genetic research include several hundreds of unique inbred strains and genetically engineered mutants. By cross
Yamamura Ken-ichi, Kawakami Minoru
doaj   +1 more source

Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose‐mediated peritoneal injury in mice

Physiological Reports, Volume 13, Issue 22, November 2025.
High‐glucose peritoneal dialysis (PD) fluid induces oxidative stress, inflammation, and fibrosis in the peritoneum. In vivo, Nnt‐deficient C57BL/6J mice showed significantly reduced PD‐induced peritoneal injury, inflammation, and fibrosis compared with Nnt‐competent C57BL/6N controls.
Margarete C. Ohse, Song Rong, Sonja Schmidt, Michael S. Balzer, Christoph Nikolin, Sibylle von Vietinghoff, Hermann Haller, Kai M. Schmidt‐Ott, Yulia Kiyan, Nelli Shushakova   +9 more
wiley   +1 more source

Strongyloides venezuelensis infection susceptibility of seven inbred strains of mice Susceptibilidade de sete linhagens isogênicas de camundongos à infecções por Strongyloides venezuelensis

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2002
A trial was carried out to investigate the susceptibility of seven strains of mice to Strongyloides venezuelensis primary and secondary experimental infections, in order to provide the basis for genetic studies about resistance.
A.F.T. Amarante, T.C.G. Oliveira-Sequeira   +1 more
doaj   +1 more source