Results 51 to 60 of about 15,253 (172)
Physiological Reports, Volume 14, Issue 7, April 2026.Abstract Housing conditions, particularly environmental enrichment (EE), can influence experimental outcomes and welfare. While EE is generally regarded as beneficial, a male bias exists in research supporting this. This study investigated whether sex differences exist in levels of BDNF in the brain and peripheral tissues in environmentally enriched ...
M. F. Herselman +4 more
wiley +1 more source
Vaccines, 2019 The type of IgG subclasses induced by vaccination is an important determinant of vaccine efficacy because the IgG subclasses vary in their biological function.
Yung-Yi C. Mosley +2 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li +8 more
wiley +1 more source
Sex differences in the physiological response to acute anterior cruciate ligament overuse
The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht +5 more
wiley +1 more source
Experimental Models and Molecular Pathogenesis: An Integrated Review of Alopecia
Dermatologic Therapy, Volume 2026, Issue 1, 2026.A disconnect between mechanistic discovery and the physiological relevance of preclinical models fundamentally hampers the development of effective therapies for alopecia. This review critically bridges the pathogenic underpinnings of major hair loss disorders—androgenetic alopecia, alopecia areata, telogen effluvium, and chemotherapy‐induced anagen ...
Yuexin Fu +5 more
wiley +1 more source
Journal of Lipid Research, 2001 Interindividual and interstrain variations in cholesterol absorptionefficiency occur in humans and animals. We investigated physiological biliaryand small intestinal factors that might determine variations in cholesterolabsorption efficiency among inbred
David Q-H. Wang +2 more
doaj +1 more source
Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. [PDF]
PLoS ONE, 2016 Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project.
Sudhir Kumar +24 more
doaj +1 more source
Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice [PDF]
Infection and Immunity, 1990 We tested the possibility that two phenotypic traits, defective activation of macrophage antileishmanial activities and susceptibility to infection with Leishmania major, were controlled by the same gene. We used P/J (susceptible) and C3H/HeN (resistant) mice to breed F1, backcross (Bx), and F2 mice that were tested individually for both traits, each ...
A H, Fortier, A, Tong, C A, Nacy
openaire +2 more sources
Physiological Reports, Volume 13, Issue 24, December 2025.Abstract The main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β‐catenin homolog, plakoglobin, in the regulation of ...
Frederic Abou Azar +6 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1988 Dez clones isolados das cepas Y, CL e MR foram caracterizados segundo infectividade das culturas, curvas de parasitemia, polimorfismo e mortalidade em camundongos C3H isogênicos.
S. Marques de Araújo, E. Chiari
doaj +1 more source