Results 41 to 50 of about 15,253 (172)

Genetic analysis of intestinal cholesterol absorption in inbred mice

Journal of Lipid Research, 2001
A genetic mapping strategy was employed to identify chromosomal regions harboring genes that influence the absorption of intestinal cholesterol in the mouse.
Margrit Schwarz, Daphne L. Davis, Bertrand R. Vick, David W. Russell   +3 more
doaj   +1 more source

In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain

Scientific Reports, 2017
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer.
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J. Okano, Hideyuki Okano   +5 more
doaj   +1 more source

Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Frontiers in Nutrition, 2022
A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight.
Yingga Wu, Yingga Wu, Yingga Wu, Sumei Hu, Sumei Hu, Dengbao Yang, Li Li, Li Li, Baoguo Li, Baoguo Li, Lu Wang, Lu Wang, Lu Wang, Min Li, Min Li, Min Li, Min Li, Guanlin Wang, Guanlin Wang, Guanlin Wang, Jianbo Li, Yanchao Xu, Xueying Zhang, Xueying Zhang, Xueying Zhang, Xueying Zhang, Chaoqun Niu, Chaoqun Niu, John R. Speakman, John R. Speakman, John R. Speakman, John R. Speakman   +31 more
doaj   +1 more source

A dominant X-linked QTL regulating pubertal timing in mice found by whole genome scanning and modified interval-specific congenic strain analysis. [PDF]

PLoS ONE, 2008
BackgroundPubertal timing in mammals is triggered by reactivation of the hypothalamic-pituitary-gonadal (HPG) axis and modulated by both genetic and environmental factors. Strain-dependent differences in vaginal opening among inbred mouse strains suggest
Wangsheng Zhu, Zhongpeng Fan, Chao Zhang, Zhengxia Guo, Ying Zhao, Yuxun Zhou, Kai Li, Zhenghong Xing, Guoqiang Chen, Yinming Liang, Li Jin, Junhua Xiao   +11 more
doaj   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. [PDF]

PLoS ONE, 2014
The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4).
Theresa Alexandra Mattioli, Heather Leduc-Pessah, Graham Skelhorne-Gross, Chris J B Nicol, Brian Milne, Tuan Trang, Catherine M Cahill   +6 more
doaj   +1 more source

A Mouse Immunogenicity Model for the Evaluation of Meningococcal Conjugate Vaccines

Frontiers in Immunology, 2022
The identification of an appropriate animal model for use in the development of meningococcal vaccines has been a challenge as humans are the only natural host for Neisseria meningitidis.
Arun B. Arunachalam, Stacey Vile, Angel Rosas   +2 more
doaj   +1 more source

Analysis of the sex-specific variability of blood parameters in C3H inbred mice by using data from a long-term, high-throughput project

Physiological Research, 2021
Mice are important models for biomedical research by providing the possibility of standardizing genetic background and environmental conditions, which both affect phenotypic variability. Use of both sexes in experiments is strongly recommended because of possible differences in the outcome. However, sex-specific phenotypic variability is discussed with
Aigner, B., Rathkolb, B., Hrabě de Angelis, M., Wolf, E.   +3 more
openaire   +3 more sources

Mitochondrial‐Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC‐HETB/W Rat

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia‐Jaramillo, Nagib Ahsan, Janet C. Siebert, Sarah J. Borengasser, Norman G. Hord, Michael B. Stout, Steven Austad, Arlan Richardson   +13 more
wiley   +1 more source

Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

Respiratory Research, 2017
Background Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice.
Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf, Koustav Ganguly   +13 more
doaj   +1 more source