Results 41 to 50 of about 15,270 (172)

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

Respiratory Research, 2017
Background Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice.
Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf, Koustav Ganguly   +13 more
doaj   +1 more source

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. [PDF]

PLoS ONE, 2014
The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4).
Theresa Alexandra Mattioli, Heather Leduc-Pessah, Graham Skelhorne-Gross, Chris J B Nicol, Brian Milne, Tuan Trang, Catherine M Cahill   +6 more
doaj   +1 more source

A Mouse Immunogenicity Model for the Evaluation of Meningococcal Conjugate Vaccines

Frontiers in Immunology, 2022
The identification of an appropriate animal model for use in the development of meningococcal vaccines has been a challenge as humans are the only natural host for Neisseria meningitidis.
Arun B. Arunachalam, Stacey Vile, Angel Rosas   +2 more
doaj   +1 more source

Analysis of the sex-specific variability of blood parameters in C3H inbred mice by using data from a long-term, high-throughput project

Physiological Research, 2021
Mice are important models for biomedical research by providing the possibility of standardizing genetic background and environmental conditions, which both affect phenotypic variability. Use of both sexes in experiments is strongly recommended because of possible differences in the outcome. However, sex-specific phenotypic variability is discussed with
Aigner, B., Rathkolb, B., Hrabě de Angelis, M., Wolf, E.   +3 more
openaire   +3 more sources

Mitochondrial‐Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC‐HETB/W Rat

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia‐Jaramillo, Nagib Ahsan, Janet C. Siebert, Sarah J. Borengasser, Norman G. Hord, Michael B. Stout, Steven Austad, Arlan Richardson   +13 more
wiley   +1 more source

Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice

Vaccines, 2019
The type of IgG subclasses induced by vaccination is an important determinant of vaccine efficacy because the IgG subclasses vary in their biological function.
Yung-Yi C. Mosley, Josiah E. Radder, Harm HogenEsch   +2 more
doaj   +1 more source

Sex‐dependent effects of environmental enrichment on mood‐related behaviors, central and peripheral BDNF, and adrenal catecholamine enzymes in mice

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract Housing conditions, particularly environmental enrichment (EE), can influence experimental outcomes and welfare. While EE is generally regarded as beneficial, a male bias exists in research supporting this. This study investigated whether sex differences exist in levels of BDNF in the brain and peripheral tissues in environmentally enriched ...
M. F. Herselman, S. Y. Luo, L. Y. Lin, X. F. Zhou, L. Bobrovskaya   +4 more
wiley   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source