Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in ...
Natalia eKulesskaya+4 more
doaj +2 more sources
Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder. [PDF]
Core symptoms of human DCD modeled in BXD recombinant inbred strains of mice. Significant strain differences for all measures of motor coordination were found. Three significant quantitative trait loci and seven candidate genes for gait were identified.
Rajan JRS+6 more
europepmc +2 more sources
Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines. [PDF]
The genetic basis for analgesic properties of alcohol was studied using the BXD panel of mice and identified multiple areas of the genome influencing alcohol analgesia. By combining this genetic mapping with bioinformatic analyses of existing pain literature, candidate genes were prioritized and identified Myo6 as a potential regulator of alcohol ...
Rogers WD+3 more
europepmc +2 more sources
Lipopolysaccharide‐Induced Bone Loss in Rodent Models: A Systematic Review and Meta‐Analysis
ABSTRACT Osteoporosis has traditionally been characterized by underlying endocrine mechanisms, though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide (LPS), a component of gram‐negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone ...
Kirsten N. Bott+6 more
wiley +1 more source
CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey+4 more
wiley +1 more source
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta+8 more
core +10 more sources
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn+7 more
doaj +1 more source
Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice.
Juan-Felipe Perez-Correa+6 more
doaj +1 more source
DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. [PDF]
Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction.
Harriet M Jackson+8 more
doaj +1 more source
Data-Driven Design-by-Analogy: State of the Art and Future Directions [PDF]
Design-by-Analogy (DbA) is a design methodology wherein new solutions, opportunities or designs are generated in a target domain based on inspiration drawn from a source domain; it can benefit designers in mitigating design fixation and improving design ideation outcomes.
arxiv +1 more source