Results 21 to 30 of about 48,234 (239)

Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: implications for interventions based on social enrichment

Frontiers in Behavioral Neuroscience, 2014
Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in ...
Natalia eKulesskaya, Nina N Karpova, Li eMa, Li eTian, Vootele eVoikar   +4 more
doaj   +2 more sources

Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder. [PDF]

Genes Brain Behav
Core symptoms of human DCD modeled in BXD recombinant inbred strains of mice. Significant strain differences for all measures of motor coordination were found. Three significant quantitative trait loci and seven candidate genes for gait were identified.
Rajan JRS, Gill K, Chow E, Ashbrook DG, Williams RW, Zwicker JG, Goldowitz D.   +6 more
europepmc   +2 more sources

Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines. [PDF]

Addict Biol
The genetic basis for analgesic properties of alcohol was studied using the BXD panel of mice and identified multiple areas of the genome influencing alcohol analgesia. By combining this genetic mapping with bioinformatic analyses of existing pain literature, candidate genes were prioritized and identified Myo6 as a potential regulator of alcohol ...
Rogers WD, Presley A, Damaj MI, Miles MF.   +3 more
europepmc   +2 more sources

Lipopolysaccharide‐Induced Bone Loss in Rodent Models: A Systematic Review and Meta‐Analysis

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 198-213, January 2023., 2023
ABSTRACT Osteoporosis has traditionally been characterized by underlying endocrine mechanisms, though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide (LPS), a component of gram‐negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone ...
Kirsten N. Bott, Evelyn Feldman, Russell J. de Souza, Elena M. Comelli, Panagiota Klentrou, Sandra J. Peters, Wendy E. Ward   +6 more
wiley   +1 more source

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey, Jayshen Arudkumar, Annemieke Aartsma‐Rus, Fatwa Adikusuma, Paul Q. Thomas   +4 more
wiley   +1 more source

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]

, 2016
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta, Gong, Ke Wei, Lusis, Aldons J, Rau, Christoph, Ren, Shuxun, Romay, Milagros C, Stolin, Gabriel, Wang, Jessica Jen-Chu, Wang, Yibin   +8 more
core   +10 more sources

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source

Epigenetic Clocks for Mice Based on Age-Associated Regions That are Conserved Between Mouse Strains and Human

Frontiers in Cell and Developmental Biology, 2022
Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice.
Juan-Felipe Perez-Correa, Juan-Felipe Perez-Correa, Vithurithra Tharmapalan, Vithurithra Tharmapalan, Hartmut Geiger, Wolfgang Wagner, Wolfgang Wagner   +6 more
doaj   +1 more source

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2015
Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction.
Harriet M Jackson, Kristen D Onos, Keating W Pepper, Leah C Graham, Ellen C Akeson, Candice Byers, Laura G Reinholdt, Wayne N Frankel, Gareth R Howell   +8 more
doaj   +1 more source

Data-Driven Design-by-Analogy: State of the Art and Future Directions [PDF]

Journal of Mechanical Design. 144(2), 2022, 020801, 2021
Design-by-Analogy (DbA) is a design methodology wherein new solutions, opportunities or designs are generated in a target domain based on inspiration drawn from a source domain; it can benefit designers in mitigating design fixation and improving design ideation outcomes.
arxiv   +1 more source