A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. [PDF]
PLoS ONE, 2009 Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Richard Williams +13 more
doaj +10 more sources
Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains [PDF]
European Journal of Translational Myology, 2017 Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents.
Dario Coletti +2 more
doaj +5 more sources
Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol? [PDF]
Frontiers in PsychiatryUnder conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed +4 more
doaj +2 more sources
Effects of housing density in five inbred strains of mice. [PDF]
PLoS ONE, 2014 To evaluate the effect of increased mouse density in a cage, mice were housed at the density recommended by the 1996 Guide for the Care and Use of Laboratory Animals and at densities that were approximately 2, 2.6, and 3 times greater.
Judith L Morgan +8 more
doaj +6 more sources
The genetic architecture of NAFLD among inbred strains of mice
eLife, 2015 To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a diet
Simon T Hui +14 more
doaj +5 more sources
In silico candidate variant and gene identification using inbred mouse strains [PDF]
PeerJ, 2021 Mice are the most widely used animal model to study genotype to phenotype relationships. Inbred mice are genetically identical, which eliminates genetic heterogeneity and makes them particularly useful for genetic studies.
Matthias Munz +4 more
doaj +2 more sources
Scientific Reports, 2023 Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice ...
Kishore R. Alugupalli +11 more
doaj +1 more source
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. [PDF]
, 2020 Epidemiological studies of human longevity found two interesting features, robust advantage of female lifespan and consistent reduction of lifespan variation.
Bartke, Andrzej +8 more
core +3 more sources
Sperm morphology in two house mouse subspecies: do wild-derived strains and wild mice tell the same story? [PDF]
PLoS ONE, 2014 Being subject to intense post-copulatory selection, sperm size is a principal determining component of male fitness. Although previous studies have presented comparative sperm size data at higher taxonomic levels, information on the evolution of sperm ...
Jana Albrechtová +4 more
doaj +1 more source
Медицинская иммунология, 2014 . The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium ...
D. V. Balunets +5 more
doaj +3 more sources