High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
, 2015 Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A +6 more
core +1 more source
Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains
Frontiers in Physiology, 2017 Changes in cardiorespiratory fitness in response to a standardized exercise training protocol differ substantially between individuals. Results from cross-sectional, twin, and family studies indicate genetics contribute to individual differences in both ...
Joshua J. Avila +2 more
doaj +1 more source
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli [PDF]
, 2015 Aberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction.
ANDOLINA, DIEGO +2 more
core +1 more source
Variability in empathic fear response among 11 inbred strains of mice
Genes, Brain and Behavior, 2016 Empathy is an important emotional process that involves the ability to recognize and share emotions with others. We have previously developed an observational fear learning (OFL) behavioral assay to measure empathic fear in mice. In the OFL task, a mouse
S. Keum +6 more
semanticscholar +1 more source
Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. [PDF]
PLoS ONE, 2010 Progressive sensorineural hearing loss is the most common form of acquired hearing impairment in the human population. It is also highly prevalent in inbred strains of mice, providing an experimental avenue to systematically map genetic risk factors and ...
Konrad Noben-Trauth +3 more
doaj +1 more source
Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]
, 2004 Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S. +7 more
core +5 more sources
PLoS Genetics, 2015 Common forms of atherosclerosis involve multiple genetic and environmental factors. While human genome-wide association studies have identified numerous loci contributing to coronary artery disease and its risk factors, these studies are unable to ...
Brian J. Bennett +16 more
semanticscholar +1 more source
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]
, 2016 We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta +8 more
core +12 more sources
Spontaneous Testicular Teratomas in an Inbred Strain of Mice [PDF]
Proceedings of the National Academy of Sciences, 1954 Descriptions of teratoid tumors of the mammalian testis, other than for man and ie horse, are ,are. In mice'oteratoma testis has not heretofore been reported. urthermore,.there are only a few descriptions of the ovarian counterpart of this 'pe of tumor in the mouse.", 2, 3, 4 In view of the paucity of information concerng teratomas in mice, their ...
Stevens, L C, Little, C C
openaire +3 more sources
Laboratory Animal Research, 2018 Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam +5 more
doaj +1 more source