Laboratory Animal Research, 2018 Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam +5 more
doaj +1 more source
Empirical likelihood for estimating equations with missing values [PDF]
Annals of Statistics 2009, Vol. 37, No. 1, 490-517, 2009 We consider an empirical likelihood inference for parameters defined by general estimating equations when some components of the random observations are subject to missingness. As the nature of the estimating equations is wide-ranging, we propose a nonparametric imputation of the missing values from a kernel estimator of the conditional distribution of
arxiv +1 more source
The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. [PDF]
, 2017 Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation.
Hallgrímsson, Benedikt +4 more
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The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]
, 2016 The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman +10 more
core +3 more sources
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli [PDF]
, 2015 Aberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction.
ANDOLINA, DIEGO +2 more
core +1 more source
Analysis of microsatellite polymorphism in inbred knockout mice. [PDF]
PLoS ONE, 2012 Previously, we found that the genotype of 42 out of 198 mouse microsatellite loci, which are distributed among all chromosomes except the Y chromosome, changed from monomorphism to polymorphism (CMP) in a genetically modified inbred mouse strain. In this
Baofen Zuo +8 more
doaj +1 more source
Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]
, 2004 Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S. +7 more
core +5 more sources
Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping
Frontiers in Genetics, 2019 The interfrontal bone (IF) is a minor skeletal trait residing between the frontal bones. IF is considered a quasi-continuous trait. Genetic and environmental factors appear to play roles in its development. The mechanism(s) underlying IF bone development
Heather Zimmerman +4 more
doaj +1 more source
Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice
Genome Biology, 2022 Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the
Ming Liu +21 more
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Genetic Variation in the Development of Mouse Brain and Behavior: Evidence from the Middle Postnatal Period [PDF]
, 1975 Six inbred strains and 3 F2 hybrid crosses of mice were assessed for developmental status at 32 days after conception (about 13 days after birth). Phenotypes measured included body weight, brain weight, maturity of 14 reflexive behaviors, myelination of ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
core +1 more source