Results 41 to 50 of about 145,801 (250)

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson   +9 more
doaj   +1 more source

Ethanol Teratogenesis in Five Inbred Strains of Mice [PDF]

Alcoholism: Clinical and Experimental Research, 2009
Background: Previous studies have demonstrated individual differences in susceptibility to the detrimental effects of prenatal ethanol exposure. Many factors, including genetic differences, have been shown to play a role in susceptibility and resistance, but few studies have investigated the range of genetic variation in rodent models.Methods: We ...
Hali Broncucia, Thomas E. Johnson, Christina Balderrama-Durbin, Chris Downing, David S. Gilliam   +4 more
openaire   +3 more sources

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, Stacey M. Hartwig, John T. Harty, John T. Harty, John T. Harty, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +9 more
doaj   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes. [PDF]

PLoS Genetics, 2005
Evidence from inbred strains of mice indicates that a quarter or more of the mammalian genome consists of chromosome regions containing clusters of functionally related genes.
Petko M Petkov, Joel H Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L King, Kenneth Paigen   +5 more
doaj   +2 more sources

QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains [PDF]

, 2009
Peer reviewedPublisher ...
Blizard, David A, Koide, Tsuyoshi, Kuriki, Satoshi, Lionikas, Arimantas, Nishi, Akinori, Sakaguchi, Takayuki, Umemori, Juzoh   +6 more
core   +3 more sources

A novel strategy for delivering Niemann‐Pick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus

Journal of Neurochemistry, Volume 164, Issue 1, Page 6-28, January 2023., 2023
Brain endothelial cells (BECs), denoting the blood–brain barrier (BBB), can be specifically transduced both in vitro and in vivo following intravenous administration of the AAV‐BR1 vector, which onsets the synthesis of recombinant NPC2 protein from the BECs.
Charlotte Laurfelt Munch Rasmussen, Eva Hede, Lisa Juul Routhe, Jakob Körbelin, Steinunn Sara Helgudottir, Louiza Bohn Thomsen, Markus Schwaninger, Annette Burkhart, Torben Moos   +8 more
wiley   +1 more source

Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome

Journal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022
Virgin female mice show enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome. When tested in an anxiogenic novel cage environment, prenatally androgenised (PNA) female mice rapidly retrieve and nest with pups, with most control females failing to complete the retireval task.
Zin Khant Aung, Renee R. Masih, Elodie Desroziers, Rebecca E. Campbell, Rosemary S. E. Brown   +4 more
wiley   +1 more source

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Behavioral and Brain Functions, 2011
Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both ...
Grabowski-Boase Laura, Eisener-Dorman Amy F, Tarantino Lisa M   +2 more
doaj   +1 more source