Results 51 to 60 of about 259,574 (259)
Frontiers in Immunology, 2017 Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin +9 more
doaj +1 more source
Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]
, 2013 It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P +5 more
core +2 more sources
Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes. [PDF]
PLoS Genetics, 2005 Evidence from inbred strains of mice indicates that a quarter or more of the mammalian genome consists of chromosome regions containing clusters of functionally related genes.
Petko M Petkov +5 more
doaj +2 more sources
mBio, 2022 Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn +7 more
doaj +1 more source
Strain variation in spermatozoal glycosidases in inbred mice
Genetical Research, 1978 SUMMARYTen glycosidases were measured in suspensions of spermatozoa from the vasa deferentia of two inbred mouse strains and their intercrosses. Eight of these glycosidases were associated with the sperm cells and all of these showed genetical variation between the strains except α-l-fucosidase with optimal activity at pH 5·4.
Self, S J, Winchester, B G, Archer, J R
openaire +3 more sources
Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]
, 2002 Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R. +4 more
core +2 more sources
Genetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J +11 more
core +1 more source
Susceptibility differences of inbred strains of mice to blastomycosis [PDF]
Infection and Immunity, 1981 The susceptibility of inbred strains of mice to pulmonary blastomycosis was studied to derive information relevant to host resistance and genetic background. Initial studies with eight strains with various H-2 backgrounds revealed the C3H/HeJ strain to be highly susceptible and DBA/1J mice to be resistant. These observations were confirmed with various
Morozumi, P A +2 more
openaire +3 more sources
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. [PDF]
, 2009 We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation ...
Beier, David R +8 more
core +1 more source
Tympanometry assessment of 61 inbred strains of mice [PDF]
Hearing Research, 2007 Otitis media (OM) accounts for more than 20 million clinic visits in the United States every year. Resistance to antibiotics has hampered current management of the disease. Identification of genetic factors underlying susceptibility to OM is greatly needed in order to develop alternative treatment strategies.
Zheng, Q Y +3 more
openaire +4 more sources