Results 71 to 80 of about 145,801 (250)
Hydronephrosis in inbred strains of mice with particular reference to the BRVR strain [PDF]
Laboratory Animals, 1973 Hydronephrosis occurred in 6 of the 13 inbred mouse strains maintained in the same colony. Its incidence was high only in the BRVR strain, where about half of the cases could only be detected microscopically. There was no concomitant infection even in severely abnormal BRVR kidneys and the incidence of the condition was not influenced by dietary ...
Taylor, D M, Fraser, H
openaire +3 more sources
Lifespan modulation in mice and the confounding effects of genetic background [PDF]
, 2014 We are currently in the midst of a revolution in ageing research, with several dietary, genetic and pharmacological interventions now known to modulate ageing in model organisms.
Mulvey, Lorna +2 more
core +1 more source
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source
Laboratory Animal Research, 2022 Background Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding.
Hajin Nam +8 more
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Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice [PDF]
Veterinary Pathology, 2019 During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis ...
Cooper, Timothy K +7 more
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Animal Models and Experimental Medicine, EarlyView.It is increasingly recognized that young, chow‐fed inbred mice poorly model the complexity of human carcinogenesis in multiple respects. In humans, age and adiposity are the major risk factors for the majority of malignancies. Although the development of genetically engineered mouse models (GEMM) of cancer has recapitulated many aspects of human cancer,
Iqbal M. Lone +4 more
wiley +1 more source
SPERMATOGENESIS INDICES IN INBRED STRAINS DD/HE AND BALB/CLAC AND THEIR F1 RECIPROCAL CROSSES
Вавиловский журнал генетики и селекции, 2014 We have shown that among 13 inbred mice strains males the DD/He strain has the lowest proportion of mobile sperm and moderate sperm count and proportion of abnormal sperm heads.
M. A. Kleshchev +2 more
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Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]
, 2003 Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Blank, T. (Thomas) +5 more
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.The exon 16 of the mouse Apc gene was targeted with CRISPR/Cas9 system and a novel Apc knockout mouse model was generated by creating a frameshift mutation at codon 750 (ApcΔ750). The polyp number, polyp distribution and the overall survival of mice carrying the ApcΔ750 allele significantly differs between the F8‐FVB‐ApcΔ750 and F4‐B6;FVB‐ApcΔ750 mouse
Sarp Uzun +7 more
wiley +1 more source
Inbred mouse strains and genetic stability: a review
Animal, 2011 Inbred mice were essential animal models for scientific research during the 20th century and will contribute decisive results in the current and next centuries.
J. Casellas
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