Results 71 to 80 of about 128,575 (177)

Effects of Housing Density in Five Inbred Strains of Mice

PLoS ONE, 2014
To evaluate the effect of increased mouse density in a cage, mice were housed at the density recommended by the 1996 Guide for the Care and Use of Laboratory Animals and at densities that were approximately 2, 2.6, and 3 times greater. Five strains of mice (129S1/SvImJ, A/J, BALB/cByJ, C57BL/6J, and DBA/2J) were evaluated throughout 3- and 8-month ...
Morgan, Judy, Svenson, Karen L, Lake, Jeffrey P, Zhang, Weidong, Stearns, Timothy M, Marion, Michael A, Peters, Luanne L, Paigen, Beverly J, Donahue, Leah Rae   +8 more
openaire   +6 more sources

Mucopolysaccharidosis Type IIIB With Pancytopenia: A Case Report and Hematological Correlations in Mice

Clinical Genetics, EarlyView.
We report an individual with mucopolysaccharidosis type IIIB and chronic pancytopenia. Hematological studies in a mouse model revealed microcytic anemia and decreased monocyte count. Hence, pancytopenia is thought to be secondary to mucopolysaccharidosis type IIIB, and we suggest that a complete blood count should be included in the clinical ...
Éliane Beauregard‐Lacroix, Patricia Dubot, Alexey V. Pshezhetsky, Philippe M. Campeau   +3 more
wiley   +1 more source

On the Identifiability of Genetic Parameters for Growth in Mice With a Massively Deep Pedigree

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In models with direct and maternal genetic effects, structural features of the data are a potential source of bias and low accuracy of estimates for genetic covariance parameters. One of the well‐known reasons for such poor practical identifiability is the lack of dams with own observations.
X. Ding, A. A. Musa, N. Reinsch
wiley   +1 more source

Genetics of MuBl and of a complement defect in inbred strains of mice

Genetical Research, 1966
A mouse antigen, MuB1, has been shown by the study of backcrosses to be inherited in a unifactorial dominant manner. Its inheritance is not linked with gamma globulin allotypes, but has been shown to be linked with the presence of the haemolytic complement system.
Cinader, B, Dubiski, S, Wardlaw, A C
openaire   +3 more sources

The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus

Molecular Ecology, EarlyView.
ABSTRACT Chromosomal inversion polymorphisms are ubiquitous across the diversity of diploid organisms and play a significant role in the evolution of adaptations in those species. Inversions are thought to operate as supergenes by trapping adaptive alleles at multiple linked loci through the suppression of recombination. While there is now considerable
Leslie M. Kollar, Lauren E. Stanley, Sunil K. Kenchanmane Raju, David B. Lowry, Chad E. Niederhuth   +4 more
wiley   +1 more source

Immunomodulation of salivary gland function due to cancer therapy

Oral Diseases, EarlyView.
Abstract Functional salivary glands (SG) are essential for maintaining oral health, and salivary dysfunction is a persistent major clinical challenge. Several cancer therapies also have off‐target effects leading to SG dysfunction. Recent advances highlight the role of SG immune populations in homeostasis, dysfunction and gland regeneration.
Ana C. Costa‐da‐Silva, Carlos U. Villapudua, Matthew P. Hoffman, Marit H. Aure   +3 more
wiley   +1 more source

Maize leaf yellowing gene ZmCAAX modulates growth and drought resistance by regulating abscisic acid contents through interaction with the ABA biosynthetic enzyme ZmNCED3

Plant Biotechnology Journal, EarlyView.
Summary In maize (Zea mays L.), leaves are essential for photosynthesis and transpiration and leaf yellowing is regulated by carotenoid metabolism, hormonal signalling and environmental factors. However, the molecular mechanisms linking drought stress and leaf yellowing remain poorly understood.
Xiaohu Li, Bin Zhang, Jiyuan Du, Shuai Chen, Yujiao Wang, Qigui Li, Shilin Zhuge, Xinzheng Li, Yongxin Nie, Gaoke Li, Fang Xu, Aiguo Yang, Zhiming Zhang, Haiping Ding   +13 more
wiley   +1 more source

Technical considerations and review of urinary microRNAs as biomarkers for chronic kidney disease in dogs and cats

Veterinary Clinical Pathology, EarlyView.
Abstract MicroRNAs (miRNAs or miRs) are small, non‐coding RNAs that play a crucial role in gene regulation, making them potential biomarkers for various diseases. In the field of veterinary medicine, there is a growing interest in exploring the diagnostic and therapeutic potential of miRNAs in kidney diseases affecting dogs and cats.
Candice P. Chu, Mary B. Nabity
wiley   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source