Results 81 to 90 of about 128,575 (177)

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Gluten‐free breadsticks with Ganoderma‐fermented corncobs: technological and nutritional features

Journal of the Science of Food and Agriculture, Volume 105, Issue 9, Page 4916-4926, July 2025.
Abstract Background This study investigates the use of corncobs before and after fermentation with Ganoderma annularis (G) to enhance the nutritional value of gluten‐free breadsticks. Medicinal mushrooms are known to increase the nutrient profile of substrates through solid‐state fermentation (SSF); nevertheless, using the entire SSF – as adopted in ...
Carola Cappa, Giulia Castorina, Giovanni Fiorillo, Maria Cristina Casiraghi, Manuela Rollini, Gabriella Consonni, Daniela Erba, Noemi Negrini, Alessandra Marti   +8 more
wiley   +1 more source

How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli

Brain and Behavior, Volume 15, Issue 6, June 2025.
IVC housing conditions cause significant changes in behavioral patterns, metabolism, and nociceptive responses in mice. ABSTRACT Introduction Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research.
Aslı Çelik, Cemre Ural, Hatice Efsun Kolatan, Pembe Keskinoğlu, Mehmet Ateş, Zahide Çavdar, Osman Yılmaz, Mehmet Ensari Güneli   +7 more
wiley   +1 more source

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT The invention of a therapeutic begins by characterizing features that differentiate healthy versus diseased states; this often presents as changes in the concentration of an analyte. Examples include elevated blood glucose in diabetes, high cholesterol in heart disease, and protein aggregation in neurodegeneration.
Rebecca A. Kohnz, Dan Zhou, Bin Lou, Huifang Yao, David McKenney, Dhiraj Dokwal, Ruth Villanueva, Heidi Kocalis, Jeanine E. Ballard, Jennifer Piesvaux, Stephen F. Previs   +10 more
wiley   +1 more source

Highly efficient Agrobacterium rhizogenes‐mediated gene editing system in Salvia miltiorrhiza inbred line bh2‐7

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2406-2417, June 2025.
Summary The CRISPR/Cas9 system is a powerful tool for genomic editing with significant potential for gene function validation and molecular breeding in medicinal plants. Salvia miltiorrhiza, a model medicinal plant, was among the pioneers to utilize CRISPR/Cas9 technology, though achieving high‐efficiency homozygous knockout mutants has been ...
Mei Tian, Linglong Luo, Baolong Jin, Jianing Liu, Tong Chen, Jinfu Tang, Ye Shen, Haiyan Zhang, Juan Guo, Huawei Zhang, Guanghong Cui, Luqi Huang   +11 more
wiley   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Development of a Mouse Model of Uremic Cardiomyopathy: Investigating the Impact of Chronic Kidney Disease on Cardiac Function and Signaling Pathway

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Molecular changes in a mouse model of uremic cardiomyopathy. This model of 2,8‐DHA‐induced nephropathy in 129/Sv mice showed clinical features of uremic cardiomyopathy like reduced cardiac function and cardiac interstitial fibrosis and an unfavorable balance between protective and detrimental cardiac signaling.
Julia Moellmann, Katja Glandien, Barbara M. Klinkhammer, Julia Wollenhaupt, Heidi Noels, Joachim Jankowski, Corinna Lebherz, Peter Boor, Michael Lehrke, Nikolaus Marx   +9 more
wiley   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

Strain-specific differences in cerulein-induced acute and recurrent acute murine pancreatitis. [PDF]

Sci Rep
Demcsák A, Tran T, Sahin-Tóth M, Geisz-Fremy A.   +3 more
europepmc   +1 more source

Intact, recombinant, and spliced forms of endogenous mouse mammary tumor viruses in inbred and wild mice. [PDF]

J Virol
Lam O, Shaffer E, Boso G, Kozak CA.
europepmc   +1 more source