Results 151 to 160 of about 428,092 (271)

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

MK5 Regulates Microglial Activation and Neuroinflammation in Experimental Stroke Models. [PDF]

CNS Neurosci Ther
Wang X, Mao W, Du L, Wang F, Pang Y, Li Y, Xu G, Cui G.   +7 more
europepmc   +1 more source

Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration

Advanced Functional Materials, EarlyView.
Supramolecular biomimetic nanoaggregates (HFCu NAs), constructed with fluorinated histidine and copper ions via metal coordination and aromatic packing, exhibit enhanced reactive oxygen species （ROS）generation at tumor sites, which results in stepwise collapse of the extracellular matrix (ECM), affording tumor microenvironment responsive “turn‐on” 19F ...
Hui Wang, Ruxin Feng, Yan Wang, Qian Ma, Di Yuan, Xi Yang, Suying Xu, Tony D. James, Leyu Wang   +8 more
wiley   +1 more source

Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities. [PDF]

Redox Biol
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ.   +13 more
europepmc   +1 more source

Recent Advances in Highly Luminescent Carbon Dots

Advanced Functional Materials, EarlyView.
Here, a comprehensive summary of the advancements is provided in highly luminescent carbon dots across various luminescence bands since their discovery in 2004. It systematically covers the synthesis, structural characteristics, preparation strategies, and essential purification of these carbon dots, along with their applications in efficient ...
Yupeng Liu, Zhujun Huang, Xuanye Wang, Yiming Hao, Junxiang Yang, Hui Wang, Songnan Qu   +6 more
wiley   +1 more source

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model. [PDF]

Invest Ophthalmol Vis Sci
Ito S, Oyama Y, Yuasa T, Amano K, Onishi K, Izumi A, Jun AS, Ikawa M, Koizumi N, Okumura N.   +9 more
europepmc   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Revisiting the role of Substance P and CGRPα. [PDF]

Elife
Cai W, Khoutorsky A.
europepmc   +1 more source

Engineered Peptides‐Based Hybrid‐Nested Microneedle Effectively Treat Biofilm‐Infected Diabetic Wounds

Advanced Functional Materials, EarlyView.
A hybrid‐nested microneedle/cryogel scaffold (MQW‐CMg‐MOF) is designed for efficient biofilm removal and accelerated healing of diabetic wounds. The scaffold shows substantial biofilm removal in vitro and in a preclinical diabetic swine biofilm‐infected wound model compared to the control.
Syed Muntazir Andrabi, S. M. Shatil Shahriar, Yiran Tian, Farzad Hayati, Yajuan Su, Feng Zhang, Navatha Shree Sharma, Guangshun Wang, Shannon L. Wong, Zheng Yan, Guoliang Huang, Jingwei Xie   +11 more
wiley   +1 more source

Neuronal CDK5RAP3 deficiency leads to encephalo-dysplasia via upregulation of N-glycosylases and glycogen deposition. [PDF]

Cell Death Discov
Chen F, Xiang M, Wang Z, Yang F, Zhou J, Deng Z, Wang S, Li P, Tew J, Zhang W, Li H, Teng Y, Zhu X, Cai Y.   +13 more
europepmc   +1 more source