Results 211 to 220 of about 509,525 (262)

Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.

Endocrinology
Puffer MS, Yang J, Esparza LA, Rose L, Duong V, Radovick S, Kauffman AS.   +6 more
europepmc   +1 more source

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Xpaknockout mice

Seminars in Cancer Biology, 1996
The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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Knockout Mice in Xenobiotic Metabolism

Drug Metabolism Reviews, 2003
Mice in which genes for drug metabolizing enzymes have been deleted or inactivated have great potential to further our understanding of the functions of these enzymes and their role in toxicology a...
Henderson, Colin J., Otto, Diana M. E., McLaren, Aileen W., Carrie, Dianne, Wolf, C. Roland   +4 more
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Xenobiotic receptor knockout mice

Toxicology Letters, 1995
Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez, P, Fernandez-Salguero, S S, Lee, T, Pineau, J M, Ward   +4 more
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Rescue of Angiotensinogen-Knockout Mice

Biochemical and Biophysical Research Communications, 1998
Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal
J, Ishida, F, Sugiyama, K, Tanimoto, K, Taniguchi, M, Syouji, E, Takimoto, H, Horiguchi, K, Murakami, K i, Yagami, A, Fukamizu   +9 more
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Generation of dynorphin knockout mice

Molecular Brain Research, 2001
The opioid system has important roles in controlling pain, reward and addiction, and is implicated in numerous other processes within and outside the nervous system, such as mood states, immune responses, and prenatal developmental processes. The effects of the opioid system are mediated by at least three ligands, enkephalin, endorphin, and dynorphin ...
N, Sharifi, N, Diehl, L, Yaswen, M B, Brennan, U, Hochgeschwender   +4 more
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Insulin Receptor Knockout Mice

Annual Review of Physiology, 2003
▪ Abstract  To examine the role of the insulin receptor in fuel homeostasis, we and others have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born with normal features, but develop early postnatal diabetes and die of ketoacidosis.
Tadahiro, Kitamura, C Ronald, Kahn, Domenico, Accili   +2 more
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Generating Conditional Knockout Mice

2010
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene function in vivo. Knockout mice that harbor a null allele in their germline provide appropriate genetic models of inherited diseases and often exhibit embryonic or early postnatal lethality. To study gene function in adult mice and in selected cell types,
Roland H, Friedel, Wolfgang, Wurst, Benedikt, Wefers, Ralf, Kühn   +3 more
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Impact of Knockout Mice in Toxicology

Critical Reviews in Toxicology, 1997
Knockout mice obtained by homologous recombination technology may be valuable tools for in vivo investigations in toxicopathogenesis. A short review is given on the phenotype of mice with distinct deletions of cytokines and related genes. The application of these mice in pharmacological and toxicological research is discussed, with emphasis in ...
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Generation of Conditional Knockout Mice

2014
Conditional knockout mouse models are powerful tools to examine the biological and molecular function(s) of genes in specific tissues. The general procedure to generate such genetically engineered mouse models consists of three main steps. The first step is to find the appropriate genomic clone of the gene of interest and to design the cloning and ...
Kazuhito, Sakamoto, Channabasavaiah B, Gurumurthy, Kay-Uwe, Wagner   +2 more
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