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Genetic knockouts in mice: An update
Experientia, 1995Gene disruption technology in mammals, by homologous recombination in embryonic stem cells, is a powerful method to manipulate the mouse germ line. In the past decade it has produced a wealth of knowledge concerning neuronal development, neurodegenerative disorders and the roles of oncogenes, Hox genes and growth factors during development.
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Tissue-Specific Transgenic and Knockout Mice
2006Analysis of genetically engineered mice is crucial for our understanding of the in vivo function of genes and proteins in the whole organism. This includes inactivation of a gene or the generation of specific mutations. The development of knockout and transgenic technologies in the mouse, therefore, represents a powerful tool for elucidating gene ...
Porret, A. +4 more
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Molecular Medicine Today, 1999
Gene targeting has become an extremely popular method for generating mouse models of human disease. The targeting event is carried out in vitro in pluripotent embryonic stem (ES) cells, which are then used to generate chimeric founder animals by either fusion with early-stage embryos or direct injection into donor blastocysts.
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Gene targeting has become an extremely popular method for generating mouse models of human disease. The targeting event is carried out in vitro in pluripotent embryonic stem (ES) cells, which are then used to generate chimeric founder animals by either fusion with early-stage embryos or direct injection into donor blastocysts.
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Nihon rinsho. Japanese journal of clinical medicine, 2004
Here we investigated the biological functions of adiponectin, a fat-derived hormone, by disrupting the gene encodes it in mice. Adiponectin knockout mice (KO) exhibited severe diet-induced insulin resistance with reduced IRS-1-associated P13-kinase activity in muscle.
Norikazu, Maeda, Tohru, Funahashi
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Here we investigated the biological functions of adiponectin, a fat-derived hormone, by disrupting the gene encodes it in mice. Adiponectin knockout mice (KO) exhibited severe diet-induced insulin resistance with reduced IRS-1-associated P13-kinase activity in muscle.
Norikazu, Maeda, Tohru, Funahashi
openaire +1 more source