Results 221 to 230 of about 762,246 (298)

New Insights Into the Role of Polo-Like Kinase 3 in Lung Tumorigenesis. [PDF]

J Cell Biochem
Li C, Samad A, Ostrowski C, Alam SMS, Yin C, Ayyamperumal S, Chen J, Zhong M, Huang W, Wang Y, Islam HK, Phillips JL, Lee MYWT, Xu D.   +13 more
europepmc   +1 more source

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia. [PDF]

Aging Cell
Mishima T, Nagamune T, Tada S, Watanabe D, Tokuda N, Yamada T, Hashimoto-Hachiya A, Higo-Yamamoto S, Kido K, Nagaoka N, Ikedo A, Imai Y, Fujita R, Mizuno S, Takahashi S, Oishi K, Ato S, Ogasawara R.   +17 more
europepmc   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

<i>Toxoplasma gondii</i> effector GRA35 mediates neuronal damage <i>via</i> ER stress and mitochondria-associated apoptosis. [PDF]

Virulence
Wang J, Chen Y, Zhou N, Li F, Dai N, Chen Z, Liu S, An R, Chen L, Du J.   +9 more
europepmc   +1 more source

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

Advanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee, Yeongdo Lee, Enji Kim, Hunkyu Seo, Myoungjae Oh, Hanho Joo, Somin Lee, Jae‐Hyun Lee, Hyun Ho Jung, Minsuk Kwak, Jang‐Ung Park   +10 more
wiley   +1 more source

Microglial SIRT6 confers protection against neuroinflammation-associated depression through NRF2-HO1 signaling. [PDF]

Neurobiol Stress
Xu R, Zhang C, Chen K, Shi Y, Liang CR, Long CY, Li HY, He CK, Li L.   +8 more
europepmc   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1. [PDF]

Sci Rep
Saad C, Jung-Klawitter S, Dimitrov B, Aguilar-Pimentel JA, Becker L, da Silva-Buttkus P, Dragano NRV, Garrett L, Hölter SM, Rathkolb B, Sanz-Moreno A, Spielmann N, Fuchs H, Gailus-Durner V, Schaaf CP, la Marca G, Damiano R, Lefeber DJ, Engelke U, CHARLIE Consortium, de Angelis MH, Houten SM, Kölker S.   +22 more
europepmc   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source